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Do Now. Turn in Alien Invasion (staple sheets together) Get out Protein Synthesis HW Explain the difference between transcription and translation. (Hint: Think about what is made) Explain difference between codon and anticodon .

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Presentation Transcript
Do now
Do Now

  • Turn in Alien Invasion (staple sheets together)

  • Get out Protein Synthesis HW

  • Explain the difference between transcription and translation. (Hint: Think about what is made)

  • Explain difference between codon and anticodon.

    After answering the above questions get out a piece of scratch paper.


What is the protein for the dna strand below
What is the protein for the DNA strand below?

TAATACAGGTTGCGTACT

AUUAUGUCCAACGCAUGA

DNA

TRANSCRIPTION

RNA

TRANSLATION

MET

SER

ASN

ALA

STOP



Mutations
Mutations

Mutations


What is a mutation?

Change in the DNA

nitrogen base

sequence of a gene


How do mutations occur
How do Mutations Occur?

Errors in DNA Replication

Replication


How do mutations occur1
How do Mutations Occur?

Damaged DNA caused by agents such as sunlight, smoke, radiation



Two ways to classify mutations
Two ways to classify mutations

Acquired mutation

Get a mutation at some point in life.

Hint: Think of it like getting sick, but you can’t get rid of it.


Two ways to classify mutations1
Two ways to classify mutations

Inherited mutation

Get a mutation from your parents


Let s practice protein synthesis with normal dna
Let’s practice protein synthesis with normal DNA

DNA: TAC AAC GTC ACC ATT

mRNA: AUG UUG CAG UGG UAA

Amino acid: Met Leu Gln Trp STOP


Category of mutation point
Category of Mutation: Point

Change in one base of the DNA sequence.

Original: The fat cat ate the wee rat

Point mutation: The fat hat ate the wee rat




Sickle Cell Anemia Story

(Beginning to 3:00)


Category of mutation frameshift
Category of Mutation: Frameshift

Addition or deletion of a DNA base resulting in a different sequence of DNA.

Original: The fat cat ate the wee rat

Frameshift mutation: The fat ata tet hew eer at





Type of mutations missense
Type of Mutations: Missense

Change in one base of the DNA sequence which causes a change in amino acid.


Mutated example of missense
Mutated Example of Missense

DNA: TAC AAG GTC ACC ATT

mRNA: AUG UUC CAG UGG UAA

Amino acid: Met Phe Gln Trp STOP


Type of mutations nonsense
Type of Mutations: Nonsense

Change in one base of the DNA sequence which codes for a STOP codon


Mutated example of nonsense
Mutated Example of Nonsense

DNA: TAC AAC GTC ACT ATT

mRNA: AUG UUG CAG UGA UAA

Amino acid: Met Phe Gln STOP


Type of mutations silent
Type of Mutations: Silent

Change in one base of the DNA sequence which has no effect on the amino acid sequence


Mutated example of silent
Mutated Example of Silent

DNA: TAC AAT GTC ACC ATT

mRNA: AUG UUA CAG UGG UAA

Amino acid: Met Leu Gln Trp STOP


Type of mutations insertion
Type of Mutations: Insertion

Addition of one or more bases into a DNA sequence


Mutated example of insertion
Mutated Example of Insertion

DNA: TAC AAC CGT CAC CAT T

mRNA: AUG UUG GCA GUG GUA A

Amino acid: Met Leu Gly Val Val


Type of mutations deletion
Type of Mutations: Deletion

The removal of one or more bases in DNA


Mutated example of deletion
Mutated Example of Deletion

DNA: TAC AAC GCA CCA TT

mRNA: AUG UUG CGA GGU AA

Amino acid: Met Leu Arg Gly


Blame it on DNA:

Review Song


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