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Bong-Kiun Kaang Department of Brain & Cognitive Sciences Department of Biological Sciences

15, May. 2009 Inaugural Symposium. Deciphering learning and memory mechanism. Bong-Kiun Kaang Department of Brain & Cognitive Sciences Department of Biological Sciences Seoul National University. Memory and Cognition. BCS. Eating seafood with Min. Graham & Kei. G. Fado. Cognition

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Bong-Kiun Kaang Department of Brain & Cognitive Sciences Department of Biological Sciences

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  1. 15, May. 2009 Inaugural Symposium Deciphering learning and memory mechanism Bong-Kiun Kaang Department of Brain & Cognitive Sciences Department of Biological Sciences Seoul National University

  2. Memory and Cognition BCS Eating seafood with Min Graham & Kei G Fado Cognition “The psychological result of perception and learning and reasoning” “Mental functions such as the ability to think, reason, and remember”

  3. Our Main Questions Multistage memory model (Modified from Bower, 1967) Reconsolidation Reconsolidation Retrieval Rehearsed Long-term storage Sensory organs Incoming information Short-term storage Consolidation Cues Consolidation Attended to Extinction Extinction Outside world • What molecular mechanism underlies memory consolidation process ? 2) How is memory reorganized during reconsolidation process ? 3) How can we erase our bad memory?

  4. Model Organisms Aplysia Mouse 1) Largest neurons in the animal kingdom 2) Simple nervous system: 20,000 neurons 3) In vitro synapse culture 1) Transgenic animals 2) Various forms of associative memory

  5. Consolidation Consolidation Short-term memory Long-term memory - Transcription & translation-independent - Modification of existing molecules STM - Transcription & translation-dependent - Structural changes : synaptic growth LTM

  6. Consolidation of LTF in Aplysia (Lee et al., Mol Brain, 2008) • Transcription factors involved in consolidation • 5-HT receptor

  7. Reconsolidation Consolidated state ? MEMORY Protein synthesis Labile state Protein degradation Reactivated memory becomes labile and modifiable, and has to undergo some new process of stabilization depending on de novo protein synthesis. ( Misanin et al, 1968; Nader et al., 2000; Dudai, 2004 )

  8. Protein degradation and resynthesis in the synapse induced by memory retrieval

  9. Molecule to Cognition Unit: How does the brain learn to remember? Collingridge, G.L. Zhuo, M. Lee, I. Kaang, B.K. Kim, S.J. Cho, K.

  10. “Silencing” or “TB” project T.V.P Bliss & Lømo (1973) J. Physiol. Hypothesis of TB project Synaptic plasticity is both necessary and sufficient for the information storage in the brain.

  11. Memory is formed through strengthening a unique set of synaptic connection. 2) One neuron might attend to several memory circuits. If specific synapses are inactivated, specific memory would be impaired. Testing the hypothesis

  12. Synaptic specificity Event A Event B

  13. Thanks to: Lab members Deok-Jin Jang Hyoung Kim Sue-Hyun Lee Chi-Hoon Lee  Jae-Ick Kim Hyoung-Gon Ko Hye-Ryeon Lee Heejung Jun Jun-Hyeok Choi Nam-Kyung Yu Sun-Lim Choi Nuribalhae Lee Jung-Eun Kim Chuljung Kwak Suwon Park Yeon-Su Chae

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