Chromatin Modification. Reading Seminar in Computational Biology Naomi Habib 5.1.2006. Chromatin Structure. Nucleosome (histone octamer wrapped with 146 bp of DNA). Chromatin Roles. Compactization Packing ~2 meters of DNA in to a ~10 micron diameter nucleus.
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Reading Seminar in Computational Biology
Naomi Habib 5.1.2006
Nucleosome (histone octamer
wrapped with 146 bp of DNA).
Mapping Global Histone Acetylation Patterns to Gene ExpressionSiavash K. Kurdistani,1 Saeed Tavazoie,2, Michael Grunstein1Cell, June 2004
Genome-wide Map of NucleosomeAcetylation and Methylation in Yeast
Dmitry K. Pokholok, Christopher T. Harbison,
Stuart Levine, Megan Cole, Nancy M. Hannett, P. Alex Rolfe, Elizabeth Herbolsheimer,Julia Zeitlinger,Fran Lewitter, David K. Gifford,and Richard A. Young.
Cell, August 2005
Model: transcriptional activators recruit Gcn5 and Esa1 to promoters of genes upon their Activation (Robert et al., 2004) .
model: Set2 is recruited by the elongation apparatus and that it methylates during active transcription.
Genomic Maps and Comparative Analysis ofHistone Modifications in Human and Mouse
Bradley E. Bernstein, Michael Kamal, Kerstin Lindblad-Toh, Stefan Bekiranov, Dione K. Bailey, Dana J. Huebert, Scott McMahon, Elinor K. Karlsson, Edward J. Kulbokas III, Thomas R. Gingeras, reStuart L. Schreiber, and Eric S. Lander.
Cell, January 2005.
Systematic colocalization of methyl and acetyl marks reflect recruitment of complexes containing methylases and acetylases, and/or crosstalk between modifications.
cytokine and IL4R regions
-hybridizing RNA to the tiling arrays.