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P-AKT

A. *. B. Vehicle. PF502. P-AKT. total AKT. P-PRAS40. P-rpS6. total rpS6. P-ERK. Supplementary Figure S2 : In vivo effects of PF502 as a single agent on MCAS xenograft tumour growth and PI3K/ mTOR signalling .

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P-AKT

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  1. A * B Vehicle PF502 P-AKT total AKT P-PRAS40 P-rpS6 total rpS6 P-ERK Supplementary Figure S2: In vivo effects of PF502 as a single agent on MCAS xenografttumour growth and PI3K/mTORsignalling. MCAS tumour bearing mice were treated daily with vehicle, 10 mg/kg PF502. A, Tumour volume graphed as mean + SEM, n=9-10. Unpaired t test. *, p< 0.0001. B, Immunoblot of tumours harvested at 19 days. total ERK

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