Introduction to Diseases of Hematopoitic and Lymphoid System
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Introduction to Diseases of Hematopoitic and Lymphoid System Weiping Liu Department of Pathology West China Medical school of Sichuan University. disorders of hematopoitic and lymphoid system red cell disorders anemia tumors white cell disorders* myeloid cells

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Introduction to Diseases of Hematopoitic and Lymphoid System Weiping Liu Department of Pathology

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Introduction to Diseases of Hematopoitic and Lymphoid System

Weiping Liu

Department of Pathology

West China Medical school of Sichuan University

disorders of hematopoitic and lymphoid system

red cell disorders



white cell disorders*

myeloid cells

reactive : leukopenia, leukocytosis*


lymphoid cells


tumors: lymphomas *

  • Contents

  • 1.Diseases of lymphoid tissue

  • Inflammation

  • non-specific lymphadenitis

  • special infection: becteria fungus

  • parasites virus

  • Lymphoproliferative disorders, unknown causes

  • giant lymph node hyperplasia(Castleman’s disease)

  • sinus histiocytosis with massive lymphadenopathy

  • (Rosai-Dorfman disease)

  • Tumors*:

  • primary: lymphoid neoplasm*

  • secondary: metastatic tumors

  • 2. Myeloid neoplasm

  • acute myeloblastic ( myelocytic ) leukemia

  • chronic myeloproliferative disorders

  • myelodysplastic syndrome, MDS

histology and non-neoplastic disorders of lymph nodes




lymphoid neoplasms

  • lymphoid neoplasms

  • Definition

  • malignant tumors of immune system, including

  • lymphomas, lymphocytic leukemias and plasma cell

  • neoplasms.

  • involved organs and tissues

  • lymph nodes and extralymphocytic organs

  • bone marrow and peripheral blood

  • tumor cells lymphocytes – B, T and NK cell

  • Classification

  • Hodgkin lymphoma, HL

  • Hodgkin Disease, HD

  • Non-Hodgkin lymphoma,NHL

  • B-cell neoplasms

  • T and NK-cell neoplasms

  • tumors of histiocyte and dendratic cells

Hodgkin lymphoma,HL

  • Pathologic changes

  • gross appearance: almost same as that of sarcoma

  • Histologic morphology:

  • archetecture of lymph node

  • partially or completely demolished

  • cells

  • tumor cells --- R-S cell and its variants

  • reactive inflammatory cells: lymphocytes

  • eosenophils

  • histocytes

  • fibrocytes and fibroblasts

Subtypes of Hodgkin lymphoma

1. nodular lymphocyte predominanceHodgkin

lymphoma, NLPHL

2. classical Hodgkin lymphoma,CHL

lymphocyte-rich, LR

mixed cellularity, MC

lymphocyte depletion, LD

nodular sclerosis, NS



1.biopsy and recognize RS cells carefully

typical RS cells have a value for diagnosis of HL

2.immunohistochemical(IHC) staining

CD15 CD30CD20





  • Non-Hodgkin lymphoma, NHL

  • The classification on the tumors of hematopoitic and lymphoid tissues by WHO

  • B cell neoplasms

  • precusor B cell neoplasms

  • acute lymphoblastic leukemia / lymphoblasitc lymphoma

  • mature(peripheral) B cell neuplasms

  • T and NK cell neoplasmas

  • precusor T cell neoplasms

  • acute lymphoblastic leukemia / lymphoblasitc lymphoma

  • mature(peripheral) T and NK cell neuplasms

key words



2.cell size:large cell

small cell


3.immunophenotype: T; B; NK;

4.sites related:

mycosis fungoides, MF

intestinal T-cell lymphoma, ITCL

NK/T-cell lymphoma, nasal type

  • Basic pathologic changes

  • Architecture of LN is partially or completely

  • demolished

  • relatively momnmorphic lymphoid tumor cell

  • infiltrated diffusely or follicularlly

  • the lymphoid tumor cells infiltrate the

  • capsule of LN and extrnodal soft tissues

Acute lymphoblastic leukemia, BM smear

follicular lymphoma, FL滤泡型淋巴瘤


Chronic lymphocytic leukemia


Burkitt lymphoma

large B-cell lymphoma, spleen


patients children/youth people of any age

stages I / II III / IV

symptoms 40% 15%

site LN, 90% LN, 70%

neck/mediastinum extranodal,30%

dissemination predictable random

extranodal uncommon common

leukemia no yes

tumor cell R-S cells lymphocytes

  • Clinical manifestations and stages

  • Manifestations

  • Localized lymphadenopathy painlessly and progressively

  • Invasion and destroy the surrounding tissues

  • pressing the surrounding organs and tissues

  • disturbance of metabolism and functions in

  • involved organs

  • staging system

  • Ann Arbor Classification, (1971) I-IV

  • Diagnosis

  • Biopsy

  • Morphologic classification

  • Immunophenotypic detection

  • Ig and TCR gene rearrangement analysis

  • Prognosis and factors related

  • Malignant histiocytosis, MH

  • heterogeneous lymphoproliferative disorders

  • 1. T-cell lymphomas

  • 2. NK/T-cell lymphomas

  • 3. Large B-cell lymphomas

  • 4. anaplastic large cell lymphomas

  • 5. true histiocytic sarcomas

  • Clinical features


    multicentric distribution


    poor response to therapy

    poor prognosis

    high mortality

    myeloid neoplasms


    Myeloid neuplasms

    arise within hematopoietic stem cells and typically give rise to monoclonal proliferations that diffusely replace normal bone marrow cells


    1.acute myeloid leukemia, AML

    2. chronic myeloproliferative diseases, CMPD

    3. myelodysplastic syndrome, MDS

    hyperplastic marrow

    • acute myeloblastic (myeloid) leukemia,

    • ( AML )

    • Definition

    • malignant tumor of hematopoitic stem cells

    • tumor cells proliferate diffusely inside Bm

    • tumor cells extensively infiltrate outside Bm

    • usually do not form a mass or masses

    • Classification

    • short disease course

    • the number of WBC in peripheral blood:

    • leukemic / non-leukemic

    • cell involved:

    • FAB classification of AML: M1-M7

    • The classification of AML by WHO *

    • cytogenetic changes

    • with or without multicellular dysplasia

    • treatment related


    Hyperplasitc marrow

    AML BM smear

    AML BM biopsy



    • Clinical manifestation and diagnosis

    • manifestations

    • diagnosis

    • BM aspiration and hemogram

    • Bone marrow biopsy: the value in diagnosis and treatment of leukemias

    • evaluate the degree of BM hyperplasia

    • 2. to find the residual leukemic cells

    • 3. to diagnose extra-mydullary invasion of leukemia (chloroma / granulocytic sarcoma)

    • chronic myeloproliferative diseases(CMPD)

    • Definition

    • CMPDs are clonal haematopoitic stem cell disorders characterised by proliferation in the bone marrow of one or more of the myeloid lineages.

    • Classification

    • chronic myelogenous leukemia

    • chronic idiopathic myelofibrosis

    • polycythaemia vera

    • essential thrombocythaemia

    CML blood smear

    CML BM biopsy




    philadelphia 1


    Treatment, prognosis and etiology



    bone marrow transplantation



    viral infection ( HIV )


    chemical materials

    Acquired immunodeficiency syndrome


    • Definition

    • A retroviral infection caused by HIV

    • characterized by profound immunosupprssion

    • leading to the opportunistic infections, secondary

    • neuplasms and neurologic manifestations






    Clinical features and diagnosis


    • Epidemiology

    • Three ways for HIV infection :

    • sexual transmission

    • parenteral transmission

    • mother-to-infant transmission

    • Sexual transmission

    • the major way of HIV infection

    • homosexual or bisexual male predominant

    • 46% in HIV infected people

    • 56% in HIV infected men

    • heterosexual contact of members 11%

    • Parenteral transmission

    • intravenous drug abusers

    • the largest group

    • hemophiliacs

    • received large amount of F-Ⅷ or Ⅸ concentrates

    • random recipients of blood transfusion

    • Etiology

    • a human retrovirus belonging to the lentivirus family

    • two forms of HIV are isolated from patients with AIDS, HIV-1, HIV-2

    Human immunodeficiency virus


    HIV virus

    HIV virus

    • Clinical features and diagnosis

    • Mild acute illness severe disease

    • opportunistic infections

    • neuplasms

    • CNS involvement

    • Opportunistic infections

    • protozoal and Helminthic infections

    • fungal infections

    • Bacterial infections

    • viral infections

    Pneumocystis carinii pneumonia, PCP

    Histology of PCP

    Silver staining for

    pneumocystis carinii

    • Neuplasms

    • Kaposi sarcoma

    • a vascular sarcoma

    • lymphomas

    • NHL

    • highly aggressive

    • large B-cell lymphomas

    Kaposi sacoma of skin

    Primary centrol nervous system lymphoma, PCNSL

    The end

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