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Antibiotics

Antibiotics. A breakthrough in chemotherapy. Presented by: Ahmed Yehia Alaa Ibrahim Esraa Yehia. Udersuper vision of: Prof. Dr. Nabil Higazy. Important to Know. Important to Know. Some characteristics of therapeutic agents.

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Antibiotics

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  1. Antibiotics A breakthrough in chemotherapy Presented by: Ahmed Yehia Alaa Ibrahim EsraaYehia Udersuper vision of: Prof. Dr. Nabil Higazy

  2. Important to Know

  3. Important to Know

  4. Some characteristics of therapeutic agents • Destroy or prevent the activity of a parasite without injuring the cells of the host or with minor injury to its cells. • Contact with the parasite by penetrating the cells and tissues of the host in effective concentrations. • Leave unaltered the host’s natural defense mechanisms, such as phagocytosis and the production of antibodies.

  5. Examples of Chemotherapy

  6. Sulfonamide • Sulfacetamide • Silversulfadiazine • Sulfasalazine • Sulfadoxine

  7. Chemotherapy has been practiced for centuries. • This turn in events attributed to TWO DISCOVRIES

  8. Antibiotics

  9. Antibiotics • In 1929, “Alexandar Fleming” noticed that an agar plate inoculated with Staphylococcus aureus had been contaminated with a mold, because the mold was identified as a Penicillin sp., FLEMING called the antibiotic Penicillin. • In 1889, “Vuillemin” gave the first defiition of Antibiotics. “Vuillemin” “Alexandar Fleming”

  10. Characteristics of antibiotics that qualify them as chemotherapeutic agents • Should prevent the ready development of RESISTANT FORMS of the parasites. • Should not produce undesirable SIDE EFFECTS in the host. • Should not eliminate the normal MICROBIAL FLORA in the host.

  11. Names of Antibiotics

  12. How to classify Antibiotics

  13. According to spectrum

  14. According to mode of action

  15. How penicillinaffect the cell wall ?

  16. How polymxinsaffect the cell membrane ?

  17. How aminoglycoside affect the protein synthesis ?

  18. How Rifampacin & ciprofloxacin affect DNA/RNA ?

  19. How bacteria be resistant ?

  20. References • http://en.wikipedia.org/wiki/Chemotherapy • http://www.news-medical.net/health/What-is-Chemotherapy.aspx • http://en.wikipedia.org/wiki/Antibacterial • http://www.nlm.nih.gov/medlineplus/antibiotics.html • http://chemistry.tutorvista.com/biochemistry/antibiotics.html • http://www.cancerresearchuk.org/cancer-info/cancerstats/world/the-global-picture/cancer-overall-world

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