1 / 13

Nitrogen Cycle

Nitrogen Cycle. Summary of Protein and Amino Acid Metabolism. (transaminase). Transamination. Common acceptors:  -ketoglutarate (glutamate) pyruvate (alanine); oxaloacetate (aspartate). Important transaminases: Aspartate transaminase (AST)

arabela-eddery
Download Presentation

Nitrogen Cycle

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Nitrogen Cycle

  2. Summary of Protein and Amino Acid Metabolism

  3. (transaminase) Transamination Common acceptors: -ketoglutarate (glutamate) pyruvate (alanine); oxaloacetate (aspartate) Important transaminases: Aspartate transaminase (AST) (also called glutamate-oxaloacetate transaminase, GOT) High activity in heart; tool for diagnosis of heart damage Alanine transaminase (ALT) (also called glutamate-pyruvate transaminase, GPT) High activity in liver; tool for diagnosis of liver damage

  4. Oxidative Deamination

  5. Alanine – Glucose Cycle

  6. Urea Cycle

  7. O H2N C OPO32– -ketoglutarate carbamoyl phosphate -ketoglutarate glutamate malate NAD+ malate NADH pyruvate -ketoglutarate oxaloacetate aspartate aspartate glutamate NH4+ HCO3– citrulline ATP 2 ATP glutamine H2O citrulline 2Pi AMP Pi 2 ADP + Pi arginosuccinate fumarate H2O arginine ornithine O H2NCNH2 urea The Urea Cycle alanine (from muscle) glutamine (from extrahepatic tissues) cytosol ornithine mitochondrial matrix cytosol

  8. Tryptophan Fate of Carbon Atoms from Amino Acids glucogenic amino acids ketogenic amino acids

  9. Methionine (essential amino acid) Biosynthesis of Nonessential Amino Acids

  10. Glycine Heme, Purines Tyrosine Thyroid Hormones Epinephrine Dopamine Melanin Histidine Aspartate Histamine Purines, Pyrimidines Tryptophan Glutamate Seratonin GABA (gamma-aminobutyrate) Amino Acid Product(s) Amino Acids as Precursors of Other Nitrogeneous Compounds

More Related