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Inflammation and Course Themes. Nancy Long Sieber, Ph.D. Sept. 14, 2009. Challenges and Adaptation. http://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gif. http://www.siumed.edu/~dking2/crr/images/CR007b.jpg. What is the significance of injury and toxicity?.

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inflammation and course themes

Inflammation and Course Themes

Nancy Long Sieber, Ph.D.

Sept. 14, 2009

challenges and adaptation
Challenges and Adaptation

http://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gif

what is the significance of injury and toxicity
What is the significance of injury and toxicity?
  • Tissues differ in their capacity for repair
    • Epithelial cells are continuously replaced
    • Nerve cells, in general, do not divide
  • Organs also differ in their “safety factors”
    • All organs have some amount of excess capacity
    • With aging and injury, the excess capacity is lost, and this may lead to loss of function
slide5

http://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpghttp://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpg

slide6

Elevator cable for passenger elevators

has a safety factor of about 11

http://www.gkivdo.com/gkii/wire_3.jpg

slide7

Necrosis and Apoptosis

http://pubs.niaaa.nih.gov/publications/arh25-3/image01.gif

developing human hand before web apoptosis
Developing human hand before web apoptosis

http://www.i-am-pregnant.com/img/day48-hand.gif

slide9

Developing hand after web apoptosis

http://www.grg.org/breakingnews2001.htm

slide10

Modified from: http://www.chrononhotonthologos.com/inactive/strokedr/hbothera.htm

inflammation
Inflammation

http://www.uic.edu/classes/bios/bios100/lecturesf04am/inflammation01a.jpg

slide12

Inflammation

Pro-inflammatory cytokines

IL-1 IL-6 TNF

Positive acute phase reactants:

LIVER

Haptoglobin

C3

Fibrinogen

Serum amyloid A

C-reactive Protein

http www euromeds co uk allergy treatment information htm

http://www.euromeds.co.uk/allergy-treatment-information.htm

Allergen binds to IgE, which links to mast cells, triggering release of histamine.

autoimmune disease
Autoimmune Disease

http://www.mctd.eu/images/AutoimmuneDisorder.jpg

http www wellesley edu chemistry chem227 nucleicfunction cancer cancer html

Cancer

http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.htmlhttp://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html
http www wellesley edu chemistry chem227 nucleicfunction cancer cancer html1
http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.htmlhttp://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html
obesity trends among u s adults brfss 1985
Obesity Trends* Among U.S. AdultsBRFSS, 1985

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14%

www.cdc.gov

obesity trends among u s adults brfss 1986
Obesity Trends* Among U.S. AdultsBRFSS, 1986

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14%

obesity trends among u s adults brfss 1987
Obesity Trends* Among U.S. AdultsBRFSS, 1987

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14%

obesity trends among u s adults brfss 1988
Obesity Trends* Among U.S. AdultsBRFSS, 1988

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14%

obesity trends among u s adults brfss 1989
Obesity Trends* Among U.S. AdultsBRFSS, 1989

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14%

obesity trends among u s adults brfss 1990
Obesity Trends* Among U.S. AdultsBRFSS, 1990

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14%

obesity trends among u s adults brfss 1991
Obesity Trends* Among U.S. AdultsBRFSS, 1991

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19%

obesity trends among u s adults brfss 1992
Obesity Trends* Among U.S. AdultsBRFSS, 1992

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19%

obesity trends among u s adults brfss 1993
Obesity Trends* Among U.S. AdultsBRFSS, 1993

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19%

obesity trends among u s adults brfss 1994
Obesity Trends* Among U.S. AdultsBRFSS, 1994

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19%

obesity trends among u s adults brfss 1995
Obesity Trends* Among U.S. AdultsBRFSS, 1995

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19%

obesity trends among u s adults brfss 1996
Obesity Trends* Among U.S. AdultsBRFSS, 1996

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19%

obesity trends among u s adults brfss 1997
Obesity Trends* Among U.S. AdultsBRFSS, 1997

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% ≥20%

obesity trends among u s adults brfss 1998
Obesity Trends* Among U.S. AdultsBRFSS, 1998

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% ≥20%

obesity trends among u s adults brfss 1999
Obesity Trends* Among U.S. AdultsBRFSS, 1999

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% ≥20%

obesity trends among u s adults brfss 2000
Obesity Trends* Among U.S. AdultsBRFSS, 2000

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% ≥20%

obesity trends among u s adults brfss 2001
Obesity Trends* Among U.S. AdultsBRFSS, 2001

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

slide37

Obesity Trends* Among U.S. AdultsBRFSS, 2002

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

obesity trends among u s adults brfss 2003
Obesity Trends* Among U.S. AdultsBRFSS, 2003

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

obesity trends among u s adults brfss 2004
Obesity Trends* Among U.S. AdultsBRFSS, 2004

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% 20%–24% ≥25%

obesity trends among u s adults brfss 2005
Obesity Trends* Among U.S. AdultsBRFSS, 2005

(*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)

No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

slide41

http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&pg=1http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&pg=1

the women in this study did not gain weight but they did have an increase in abdominal fat
The women in this study did not gain weight, but they did have an increase in abdominal fat

http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&dpg=10

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