Stuart G. Gordon, Ph.D. Director, CCAT-San Bernardino

1. Center for Commercialization of Advanced Technology[The Steve and Stu Show]FLC Mid-Continent & Far West Regional Meeting Stuart G. Gordon, Ph.D. Director, CCAT-San Bernardino San Bernardino San Diego

2. Organizational Structure CCAT Funding from DoD thru Office of Naval Research SPAWAR Systems Center, San Diego Equal Division of Funds San Diego San Bernardino Office of Technology Transfer and Commercialization (OTTC) CCAT San Diego San Diego SDSU Foundation San Bernardino SDSU Entrepreneurial Management Center CCAT San Bernardino UCSD Jacobs School Of Engineering Active Capital Lockheed Martin Orincon Technologies UCSD CONNECT

3. Our Services • Technology Assessment • Intellectual Property Due Diligence and Technology Valuation • Market Assessment/Market Research and Analysis • Funding Research and Development • Funding Prototype Development and Validation • Business Plan Development • Business Mentoring and Management • Marketing of Technologies to Licensees • Negotiating and Drafting License and Other Contractual Agreements • Facilitate the Creation of New Businesses • Assist in Identifying Financial Resources for Entrepreneurs • Help Promote and Network our Clients • Facilitate the Introduction and Acquisition of Technologies to the Military

4. The CCAT Process • Identify areas of technology the Navy (Military) needs • Open a National Solicitation for Proposals for: • Any military or government laboratory technology with commercial potential, or • Technology from academic or businesses that address the areas of need • Have the Proposals Reviewed and Critiqued by Expert Referees to Assess the Quality and Potential of the Technologies • Written critique of proposals, select best candidate technologies • Oral presentation to panel, final selection of best technologies • Review selection with the president & Executive Committee • Assign a Client Manager to the Project • Awards for Market Studies or Business Plans • Assign the project to one of the Marketing Research Groups • Initiate the MS/BP process • Sub-award Agreements for Technology Development or Prototype Development and Testing awards • Ask recipient to review the agreement • Ask recipients to provide statement of work, milestones and budget • Execute the agreement • Analyze the Outcome of the OTTC Efforts and, with the Awardee, the Next Steps that are Required to Complete the Commercialization Process.

5. Benefits of Technology Transfer and Commercialization • Economic Development • Help Companies Develop and Commercialize New Technologies • Bring New Technology Companies • Bring New Business to Existing Companies • Build a Stronger High Technology Business Base • Increase the Demand for Educated Labor Force • Create Stronger Ties between the Business and Academic Communities • Enhance the Resources of the Academic Community • Strengthen the Technology Based Education Facilities • Provide Greater Resources for Collaboration with the Business Community • Provide Educational Opportunities for Students and Faculty • Establish CCAT as a Critical Resource for High Technology Development and Commercialization both Locally and Nationally • Be Viewed by the Navy and other Military and Government Research Laboratories as an Important Resource • Be Viewed by Academia and Small Businesses as an Important Resource to Facilitate the Commercialization of Technologies • Provide a Conduit into the Military Acquisition System

6. CCAT Metrics for Success • Commercialization or objective progress towards commercialization on CCAT funding or subsequent to CCAT funding. • Funding from another non-CCAT source (preferably peer reviewed funding (e.g. SBIR, STTR, Venture Funding, etc.)). • Significant positive Public Relations releases or reviews by others. • Transition into the DoD or DHS programs or objective evidence that such transition will take place in the near future. • Objective development activities related to the technology or the company. • Regional Economic Development • Growth in client companies and businesses supporting client companies • New Technologies licensed to Regional Companies • New Regional Companies • Objective improvement in Faculty, Staff and Student Educational Opportunities related to CCAT projects

7. CCAT Program Metrics • 23 solicitations • 621 proposals received • 130 awards for PDT&E • 154 awards for service • $3.83 million invested, leveraging more than $18.8 million from other sources [~1:5] • 35 technologies from government labs • 133 technologies (~86%) having direct application to military or homeland security needs • More than 60% of the technologies CCAT has supported are successful.

8. Success Stories - The Hearing Pill How it Works Noise causes release of toxins known as free-radicals (Fig. A) The inner ear’s antioxidant defenses are overwhelmed (Fig. B) Hearing Pill (N-acetylcysteine (NAC)) removes toxic free-radicals and prevents the events leading to cell death and permanent hearing loss (Fig C) Highlights / Impact Licensed from Naval Medical Center San Diego. OTTC funded 2 double-blind Phase I clinical studies, in cooperation with Marine Corps Recruiting Depot. One study showed a 40% reduction in hearing loss induced by acoustic trauma. ABG shipped product to chief Army otolaryngologist in Iraq (Dr. Eric McDonald) for treating hearing loss in troops. Selected for FLC’s 2005 “World's Best Technologies” Showcase. Will help reduce DoD’s $300 MM annual hearing related costs

9. Success Stories - No-Foam AFFF Pump Testing System How it Works Developed by Naval Facilities Eng’g Command, licensed to Thomas International. Through a set of fire truck specific fittings and storage tank / trailer, delivers colored water through Aqueous Film Firefighting Foam apparatus to test the delivery system, without dispensing environmentally hazardous and expensive AFFF foam. Highlights / Impact CCAT provided Prototype Development, Test & Eval funding to develop and test fittings and trailer. Develop business plan and marketing integration / commercialization plan for licensee. Significant interest from FAA, LAX, Canadian DoD

10. Success Stories - Automated Bioaerosol Management Platform How it Works Controls and monitors all aspects of an inhalation exposure, including aerosol generation, characterization, and sampling, airflow, system balancing, environmental parameters (including temperature, humidity, and pressure), animal respiration, and dose calculation to develop animal models suitable for testing medical countermeasures for respiratory acquired infectious diseases. Highlights / Impact Developed and spun out of USAMRIID. OTTC funding enabling Beta prototype being developed for Washington University / St Louis University Biodefense Center of Excellence.Has attracted significant interest from FDA, Bioshield, NIH and others

11. Success Stories - Low Vapor Pressure Chemical Hazard Detector How it Works Low volatility hazards (LVH) such as nerve agent VX and blister agent sulfur mustard (HD) are toxic and persistent hazards that can be difficult to detect because of their low vapor pressures / volatility. By adding a simple liquid Sample Heater Assembly (SHA), utilizing existing chemical heaters will greatly improve detection of persistent low volatility liquids Highlights / Impact Developed at Edgewood Chemical Biological Command. Takes advantage of currently fielded chemical detection kit M256A1. Field testing with live agents showed excellent results. Expect to begin licensing discussions with current licensees of the M2561A kit

12. Conclusion: CCAT Program • CCAT add value to the final stages of technology development and Commercialization process • CCAT has a remarkable track-record for successful commercialization of technology • As you near completion of the R&D phase of your work, and you believe you have technology with a significant government application or public commercial value, • keep CCAT in mind as a valuable source of information and critical assessment or • a path to follow during the commercialization phase of your work