LPPD Laboratory for Product and Process Design.
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LPPDLaboratory for Product
and Process Design
Rational Design of a Decision-Making Tool for Brain SurgeonsNicholas Vaičaitis, Brian Henry, Cierra M. HallLaboratory for Product and Process Design, Dept. of Bioengineering, University of Illinois at Chicago UIC Senior Design Exposition 2011, Chicago, ILAdvisor: Professor Andreas A. Linninger
Vasculature Reconstruction and Generation
Manual Vasculature Reconstruction
-No quantitative measurements
-Doctors rely on experience and qualitative information
A Tool to Provide
Illustration of the manual vasculature reconstruction process utilizing MRA imaging.
Free Growth Generation Algorithm
3. Make random point inside and connect to segment midpoint
1. Initialize domain size and make first segment
2. Scale Domain
Pt 1 (0,10 ))
Pt 1 (0,10))
4. Calculate volumeV of tree
5. Perturb bifurcation point until minimal volume of tree is found
k, # of tree segments
r, radius of segment i
l, length of segment i
Blood flow and pressure simulation on reconstructed vascular tree.
Use Free Growth Algorithm to Add Microvasculature
Brain meshes including a volumetric mesh and DTI meshes.
Karch, R., F. Neumann, et al. (1999). "A three-dimensional model for arterial tree representation, generated by constrained constructive optimization." Comput Biol Med 29(1): 19-38.
Schreiner, W. and P. F. Buxbaum (1993). "Computer-optimization of vascular trees." IEEE Trans Biomed Eng 40(5): 482-491.
Fady T. Charbel, MD, FACS. Professor and Head of the College of Medicine at UIC. Chief of Neurovascular Section.
Ali Alaraj, MD. Assistant Professor at the College of Medicine at UIC. Endovascular/Cerebrovascular.
Bullitt E, Zeng D, Gerig G, Aylward S, Joshi S, Smith JK, Lin W, Ewend MG (2005) Vessel tortuosity and brain tumor malignancy: A blinded study. Academic Radiology 12:1232-1240.
*The MR brain images from healthy volunteers used in this paper were collected and made available by the CASILab at The University of North Carolina at Chapel Hill and were distributed by the MIDAS Data Server at Kitware, Inc.*
Blood flow, pressure
Treatment outcome likelihood
Trees generated with manual reconstruction and the free growth algorithm.
Observe Physical Phenomena
-Magnetic Resonance Angiography (MRA)
-Magnetic Resonance Imaging (MRI)
-Computed Tomography (CT)
Reconstruct Patient’s Main Vasculature