Essentials of Pathophysiology. Chapter 30 Disorders of Hepatobiliary and Exocrine Pancreas Function. The liver does not play a role in glucose homeostasis. Jaundice results from an abnormally high accumulation of bile in the blood.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Essentials of Pathophysiology
The sinusoids empty into central veins, which send the blood to the hepatic vein and inferior vena cavaLiver Structure
Hepatic cells lie along the sinusoids and pick up chemicals from the blood
They modify the blood’s compositionLiver Structure(cont.)
The bile is carried to the bile duct and then to the gallbladderLiver Structur e(cont.)
The section of the liver emptying into one vein is a lobuleLiver Structure (cont.)
The gallbladder stores bile that has been produced by the liver.Question
Rationale:The liver makes bile and secretes it into the small intestine via the common bile duct. Excess bile is stored in the gallbladder, where it also enters the small intestine through the common bile duct when it is needed.Answer
Which of the following substances a does bile make more susceptible to digestive enzymes?
Rationale:Bile (produced in the liver) emulsifies fat molecules so that they are easier to digest. An emulsion is a mixture of two immiscible (unblendable) substances, in this case bile and fat.
Ms. B was prescribed an oral medication for her skin problem. She took it twice a day.
What causes jaundice? problem. She took it twice a day.
Rationale:Erythrocytes are normally broken down in the spleen at the end of their life span. The end product of RBC metabolism is bilirubin. Bilirubin is sent to the liver to be metabolized; if the liver is not functioning properly, the bilirubin accumulates and causes jaundice (an abnormal yellowing of the skin and mucous membranes).
Viral hepatitis problem. She took it twice a day.
Hepatitis A virus (HAV)
Hepatitis B virus (HBV)
Hepatitis B–associated delta virus (HDV)
Hepatitis C virus (HCV)
Hepatitis E virus (HEV)Hepatitis
Which hepatitis viruses are most likely to be the problem problem. She took it twice a day.in:
Caused by HBV, HCV, and HDV problem. She took it twice a day.
Principal worldwide cause of chronic liver disease, cirrhosis, and hepatocellular cancer
Chief reason for liver transplantation in adultsChronic Viral Hepatitis
Rationale:HBV, HCV, and HDV are all virulent strains that may lead to chronic viral hepatitis. HAV is most commonly transmitted by the fecal-oral route (e.g., contaminated food or poor hygiene) and does not typically have a chronic stage (it does not cause permanent liver damage).
Varicosities and shunts develop
Organs engorge with bloodVeins Draining into the Hepatic Portal System
Hemoglobin from old red blood cells becomes increasebilirubin
The liver converts bilirubin into bile
Why would a man with liver failure develop jaundice?The Fate of Bilirubin
liver links it
Common bile duct
Ampulla of Vater
Sphincter of Oddi
juices through a
into the blood
The exocrine pancreas produces insulin.Question
Rationale:Beta cells of the endocrine pancreas produce insulin; the exocrine pancreas produces digestive enzymes that are secreted into the small intestine through the common bile duct.Answer
5. Bile in pancreas disrupts tissues; digestive enzymes activated
1. Gallbladder contracts
2. Bile is sent down common bile duct
3. Blockage forms in ampulla of Vater: bile cannot enter duodenum
4. Bile goes up pancreatic duct