Updated guidelines for managing hiv hcv co infection
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Updated Guidelines for Managing HIV/HCV Co-Infection. John J Faragon , PharmD , BCPS, AAHIV-P Regional Pharmacy Director, NY/NJ AIDS Education and Training Center Pharmacist, HIV Medicine, Albany Medical Center. www.hcvguidelines.org Released 1/29/14!. Abbreviations. BOC – boceprevir

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Updated Guidelines for Managing HIV/HCV Co-Infection

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Updated guidelines for managing hiv hcv co infection

Updated Guidelines for Managing HIV/HCV Co-Infection

John J Faragon, PharmD, BCPS, AAHIV-P

Regional Pharmacy Director,

NY/NJ AIDS Education and Training Center

Pharmacist, HIV Medicine, Albany Medical Center


Www hcvguidelines org released 1 29 14

www.hcvguidelines.orgReleased 1/29/14!


Abbreviations

Abbreviations

  • BOC – boceprevir

  • DAA – direct acting antiviral

  • IFN – interferon

  • PEG – pegylated interferon

  • RBV WB – ribavirin, weight based dosing

  • RGT – response guided therapy

  • SMV – simeprevir

  • SOF – sofosbuvir

  • TVR – telaprevir

www.hcvguidelines.org


Ifn ineligible definitions

IFN Ineligible Definitions

  • Intolerance to IFN

  • Autoimmune hepatitis and other autoimmune disorders

  • Hypersensitivity to PEG or any of its components

  • Decompensated hepatic disease

  • History of depression, or clinical features consistent with depression

  • A baseline neutrophil count below 1500/μL, a baseline platelet count below 90,000/μL or baseline hemoglobin below 10 g/dL

  • A history of preexisting cardiac disease

www.hcvguidelines.org


Standard dosing

Standard Dosing

  • Sofosbuvir – 400mg once daily

  • Simeprevir – 150mg once daily

  • Peg Interferon – 180mcg once weekly

  • Ribavirin – weight based dosing

    • <75kg – 1000mg daily in divided doses

    • ≥75 kg – 1200mg daily in divided doses

www.hcvguidelines.org


Drug interactions considerations

Drug Interactions Considerations

  • Sofosbuvir

    • Substrate for P-glycoprotein and breast cancer resistance protein

    • Intracellular metabolism mediated by hydrolase and nucleotide phosphorylation pathways

    • Minimal drug interactions expected

  • Simeprevir

    • Mild inhibitor of CYP1A2 activity and intestinal CYP3A4

    • Does not affect hepatic CYP3A4 activity

    • Inhibits OATP1B1/3 and P-glycoprotein

    • Multiple drug interactions expected

www.hcvguidelines.org


Sofosbuvir and hiv medications 1 of 2

Sofosbuvir and HIV Medications (1 of 2)

www.nynjaetc.org


Sofosbuvir and hiv medications 2 of 2

Sofosbuvir and HIV Medications (2 of 2)

www.nynjaetc.org


Simeprevir and hiv medications 1 of 2

Simeprevir and HIV Medications (1 of 2)

www.nynjaetc.org


Simeprevir and hiv medications 2 of 2

Simeprevir and HIV Medications (2 of 2)

www.nynjaetc.org


Hiv hcv co infection gt1

HIV/HCV Co-Infection, GT1

www.hcvguidelines.org


Hiv hcv co infection gt2

HIV/HCV Co-Infection, GT2

www.hcvguidelines.org


Hiv hcv co infection gt3

HIV/HCV Co-Infection, GT3

www.hcvguidelines.org


Hiv hcv coinfection gt4

HIV/HCV Coinfection, GT4

www.hcvguidelines.org


Hiv hcv coinfection gt 5 6

HIV/HCV Coinfection, GT 5,6

www.hcvguidelines.org


Hiv hcv not recommended

HIV/HCV NOT Recommended

www.hcvguidelines.org


Other drug interactions with sofosbuvir

Other Drug Interactions with Sofosbuvir

www.nynjaetc.org


Other drug interactions with simeprevir 1 of 2

Other Drug Interactions with Simeprevir (1 of 2)

www.nynjaetc.org


Other drug interactions with simeprevir 2 of 2

Other Drug Interactions with Simeprevir (2 of 2)

www.nynjaetc.org


Select hiv hcv resources

Select HIV/HCV Resources


Www nynjaetc org

www.nynjaetc.org


Www nynjaetc org1

www.nynjaetc.org

CLICK HERE


Www nynjaetc org2

www.nynjaetc.org

CLICK HERE


Ny nj aetc www nynjaetc org

NY/NJ AETC – www.nynjaetc.org


Ny nj aetc www nynjaetc org1

NY/NJ AETC – www.nynjaetc.org


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