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Digestive System Digestive Glands. Components of Digestive Glands. ◇ small digestive glands: found in the wall of digestive tract. ◇ accessory glands (large digestive glands):. salivary glands pancreas liver. General Structure of Digestive Glands.

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slide1

Digestive System

Digestive Glands

slide2

Components of Digestive Glands

◇small digestive glands:

found in the wall of digestive tract.

◇accessory glands (large digestive glands):

salivary glands

pancreas

liver

slide3

General Structure of Digestive Glands

◇Parenchyma: ( functional portion of an organ )

acini / gland cells

ducts

◇Stroma: ( non-functional portion of an organ )

capsule

CT inside the organ.

slide5

Salivary Glands

General structure of the large salivary glands

serous acinus

mucous acinus

seromucous / mixed acinus

acinus

types

of acinus

Parenchyma

intercalated duct

striated/secretory duct

interlobular duct

excretory duct

duct

slide6

serous acinus

seromucous

/ mixed acinus

mucous acinus

intercalated duct

striated

/secretory duct

demilume

Model ( structure of the large salivary glands)

slide7

seromucous /mixed acinus

mucous acinus

serous acinus

Model

Section (H&E)

slide8

Salivary Glands

Structural Characteristic of gland Cell:

serous acinus:comprised by serous cells.

*zymogen granules in apical cytoplasm.

mucous acinus:comprised by serous cells.

*mucinogen granules in cytoplasm.

seromucous acinus:comprised by both cells.

/ mixed acinus*demilume

slide9

serous acinus:

*zymogen granules in apical cytoplasm.

slide10

Serous cell:

basal lamina (bl);

connective tissue (ct);

desmosome (d);

endothelium (en);

Golgi complex (g);

intercellular space (is);

lumen (l);

microvilli (mi);

mitochondria (m);

nucleus (nu);

RER (re);

secretion granule (sg).

10.000x.

slide11

mucous acinus:

*mucinogen granules in cytoplasm.

n

slide12

Detail of mucous cell:

Sero-mucous cell (sc);

Golgi complex (gc);

intercellular space (is);

secretion granule (sg);

lumen (l);

nucleus (n);

RER (re).

10000x.

sg

is

re

n

slide13

seromucous acinus

/ mixed acinus

demilume

slide14

Salivary Glands

acinus

duct

intercalated duct:

simple squamous/cuboidal epith.

striated/secretory duct:

simple tall columnar epith.

interlobular duct:

pseudostratified columnar epith.

excretory duct:

stratified squamous epith.

slide15

Salivary Glands

intercalated duct:

simple squamous

or cuboidal epith.

slide16

Salivary Glands

intercalated duct: simple squamous or cuboidal epith.

slide17

LM

EM

slide18

Detail ofintercalated duct cell

basal lamina (bl);

desmosome (d);

nerve fibers (nf);

Golgi complex (g);

intercellular space (is);

mitochondria (m);

nucleus (nu);

RER (re).

13.000x.

g

m

re

nu

bl

EM

slide19

Salivary Glands

striated/secretory duct:simple tall columnar epith.

slide20

Salivary Glands

striated/secretory duct

Note: the basal striations

slide21

Striated duct:

blood vessel (bv);

connective tissue (ct);

lumen (l);

nucleus (nu).

×2750.

slide22

Basal portion of striated duct cell:

basal lamina (bl);

basal membrane pleat (bmp);

collagen fiber (cf);

mitochondria (m);

nucleus (nu).

×16.500 .

slide23

Salivary Glands

striated/secretory duct

The secretory ducts,which are continuous with the intercalated ducts,are wider and lined with a simple columnar epithelium. As the secretion from the acini passes through the secretory ducts,the epithelium can re-absorb sodium(Na+) and water from the lumen to the interstitium(间质)and transport potassium (K+) into the saliva,thus changing the consistency of the saliva. The secretory ducts drain into interlobular ducts which run between lobules.

slide24

Salivary Glands

interlobular duct:

pseudostratified columnar epith.

excretory duct:

stratified squamous epith.

slide25

Salivary glands

include

*Parotid G.

*Submandibular G.

* Sublingual G.

Function:

* moistening food.

* carbohydrate digestion.

* Secrete IgA.

slide26

Structural Features of Salivary Glands

Parotid G.

Submandibular G.

Sublingual G.

Serous A.

+++

+++++

+

Mucous A.

none

+

+++

Mixed A.

none

+

+

Inter-

calated D

none

short

long

few

long

short

Striated D

slide27

Pancreas

The pancreas is a lobular organ.

The pancreas has both exocrine functions (releases digestive enzyme secretions into the intestines) and endocrine functions (releases hormones into the blood).

slide28

Pancreas

Parenchyma

endocrine gland

exocrine gland

produces

hormones

produces

pancreatic juice

slide29

Parenchyma

make section

slide30

Parenchyma

endocrine

gland

endocrine

gland

exocrine

gland

exocrine

gland

exocrine

gland

slide31

Parenchyma

exocrine

gland

endocrine

gland

slide32

Pancreas

Exocrine Pancreas

Acini

Ducts

intercalated ducts

interlobular ducts

main pancreatic ducts

  • wholly consists of serous acini.
  • small centroacinar cells in the lumen.

major duodenal papilla

slide33

Exocrine Pancreas

Here is another look at the Exocrine Pancreas and the Acini (white dotted lines) which make it up.

Central

Acinar Cells

The yellow arrows are pointing to the characteristic centroacinar cells

which are the key to identifying the pancreas. Notice how they stand out against the dark cells of the acini.

Pancreas Acinus

slide34

Exocrine Pancreas

Centroacinar Cell

Pancreas Acinus

Acinar

Cell

Low power

(LM)

high power

(LM)

slide35

Exocrine Pancreas

  • Ducts
  • Intercalated ducts: simple squamous
  • or cuboidal epith.
  • Interlobular ducts:columnar epith.
  • pancreatic ducts: tall columanr epth.

(similar to salivary glands. REMEMBER: there are no striated ducts in the pancreas. )

major duodenal papilla

slide36

Exocrine Pancreas

It releases the pancreatic juice.

pancreatic juice contain many kinds of enzyme:

* amylase(胰淀粉酶):hydrolyses starch & glycogen .

* lipase(胰脂肪酶):hydrolyzes triglycerides(甘油三酯).

into fattyacids and mono-glycerides(甘油单酯).

* cholesterol esterase(胆固醇酯酶) :breaks down

cholesterol esters(酯)into cholesterol and a fatty acid.

* trypsin( 胰蛋白酶)and chymotrypsin(糜蛋白酶) :

hydrolyze proteins.

* ribonuclease(核糖核酸酶)& deoxyribonuclease(脱氧核

糖核酸酶):split nucleic acids.

slide37

Pancreas

Endocrine Pancreas

  • Islets of Langerhansscatter throughout the exocrine pancreas.
  • Three types of cells :
  • A-cells(20%) glucagon
  • B-cells(75%) insulin
  • D-cells( 5% ) somatostatin
  • Capillaries:each islet is richly supplied with blood vessels.
slide38

Pancreas

Endocrine Pancreas

D-cells

A-cells

B-cells

A-cells

A-cells

B-cells

slide42

Liver

General Introduction

*The largest gland (~ 2% of body weight in adult).

* Respectively receives both venous & arterial blood

through the portal V. (~75%) & hepatic A (~25%). * CT of capsule extended into the parenchyma,

forming “classical” liver loblules.

* Functions as an exocrine gland (secreting bile)

and other very important roles.

slide43

Liver

liver loblules

section

slide44

Liver

Structures of Liver Lobule

slide45

Liver

Structures of Liver Lobule

slide47

Liver

Structures of Liver Lobule

*six-sided prism

with a central V. at its center.

*sheets of hepatocytes( orhepatic plates)

extend radially from the central V.

* sinusoids between hepatic plates.

portal triads ( or portal area):

in the corner of lobules.

slide48

Liver

Structures of Liver Lobule

hepatic plates

slide49

Liver

Portal Triads (or Portal Area)

* Definition:

The area of CT found in the angles

where adjacent hepatic lobules meet.

* Components:

CT. + portal triad

interlobularA

interlobularV

interlobularbile duct

slide50

Liver

Portal Triads (or Portal Area)

slide51

Liver

Portal Triads (or Portal Area)

interlobularV

interlobular bile duct

interlobularA

slide52

Liver

Sinusoids

* Dilated anastomosing(吻合) venules

between the hepatic plates.

* Blood pathway: periphery central V.

* Kupffer cells line in the wall of sinusoids.

* EM ( endothilium of sinusoid )

significant gaps;

numerous fenestration;

incomplete basal lamina.

slide53

Liver

Sinusoids

Model

slide54

Sinusoids

Sinusoids

SEM

slide55

Scanning Electron M.(SEM)

Ec: Erythrocyte; BC: Bile Canaliculus

DS: Disse’s Space S: Sinusoid

H: Hepatocyte Mv: Microvili

slide56

Sinusoids

fenestration

endothilium

SD: Space of Disse

TEM

slide57

Sinusoids

Kupffer Cell

(LM)

Kupffer Cell

(TEM)

slide58

Liver

Hepatocyte

* typically large polyhedral cells with large round

centrally located nucleus.

* abundance of organelles relates to its functions:

Mitochondria: provide energy

RER:protein synthesis

SER:bile formation / metabolism of lipids and

hormones / detoxification.

Lysosome:defence

Microbody:detoxification.

Inclusions:glcogen particles, lipid droplets

and pigments.

slide59

Liver

Hepatocyte

MODEL

slide62

Liver

Functions of Hepatocyte

* Produce bile.

* Degrade glycogen to glucose

under regulation of hormones.

* Involve the blood lipid metabolism.

* Synthesize the blood plasma proteins:

Albumin: major plasma protein;

Fibrinogen;thrombin(凝血酶);

Clotting(凝结)factor III.

* Detoxification

slide63

Liver

Bile Canaliculus

Definition:

the tubular space limited by plasma membrane

of two adjacent hepatocytes.

Structure:

LM: network-like structures are seen

by silver impregnation.

EM: *plasma membrane of adjacent hepatocytes

forms the wall of bile canaliculi.

* tight junctions form seals.

slide64

Bile Canaliculus

Blie canaliculi stained

by silver impregnation

(LM)

slide67

Bile Canaliculus

Bile Canaliculus

Freeze Fracture SEM

slide68

Liver

Perisinusoidal space (Disse’s Space)

  • A space between endothelium & hepatocyte.
  • Bevisible under EM.
  • Occupy by numerousmicrovilliof hepatocytes.
  • Fill with blood plasma.
  • have fat-storing cells (storing fat & vitamin a)
  • A site for substance exchange
  • between the blood & the hepatocytes.
slide70

Scanning Electron M.(SEM)

Ec: Erythrocyte; BC: Bile Canaliculus

DS: Disse’s Space S: Sinusoid

H: Hepatocyte Mv: Microvili

slide72

Sinusoids

fenestration

endothilium

SD: Space of Disse

TEM

slide73

TEM

E: Erythrocyte S: Nucleus of Endothelial Cell

D: Disse’s Space BC: Bile Canaliculus

slide74

Liver

Three functional surface

on the surface of hepatocyte

*Perisinusoidal surface:

face to perisinusoidal space

*bile canalicular surface:

face into the bile canaliculus

*cell junction surface

slide75

Liver

Blood Supply

Portal V→ interlobular V → →

(75%)

sinusoids

Hepatic A→interlobular A → →

(25%)

central V

hepatic V

sublobular V

Inferior vena cava

slide76

Biliary Passages

Bile canaliculi →periperal bile ductules ( Hering’s )

interlobular bile duct

Left & right hepatic ducts

Common hepatic duct

Common bile duct

Duodenum papilla

Cystic duct

Gall bladder

slide77

Liver

Classification of Lobules

Portal lobule

Liver acinus

Classic lobule

slide78

Liver

Classic lobule

A hexagonal structure with the central vein at its center; at the six corners of the lobule are hepatic triads.

slide79

Liver

Portal lobule

A triangular structure with the portal area at its center.

Three central veins are found at the peripheral boundary points.

slide80

Liver

Liver acinus

An elongate olive-shaped lobule; a central vein is at the ends of the two elongated points of the olive.

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