NIH101. Sharon L. Milgram, [email protected] The National Institutes of Health. “The Nation’s biomedical research institution”. www.nih.gov. Composed of 27 Institutes and Centers Campuses in MD, NC, AZ, MI, and MT Two divisions -- intramural and extramural
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“The Nation’s biomedical research institution”
……. In 1250 intramural labs
My interest: Regulation of CFTR trafficking
Bill’s interest: Using mass spectrometry to identify novel protein interactions
Bill’s thesis: Using mass spectrometry to identify novel regulators
Of CFTR trafficking, turn-over, and activity
“Many of us when confronted by a writing deadline, skip the organizational phase of writing. This is akin to leaving on a trip to unknown parts without a road map, hotel reservations, or plans of any sort.”
Relevance to treatment of CF
a disease of protein trafficking and cell signaling
Status of CF drug discovery
Could novel interactors be drug targets? P’TASE data
CFTR protein interactions
How to find them?
PDZ proteins (ours & others)
Strong writing can not compensate for bad ideas, but weak writing can easily ruin good ideas
The canine was observed moving at very high velocity. Accelerate rapidly from a walk, Spot, accelerate rapidly from a walk.
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