The Depressive Behavior and Physiological Effects on CD-1 Female M ice ( Mus musculus ) Subjected to a S eries of Chronic U npredictable Stressors While on a High Flaxseed Oil Diet Caitlin Verhalen , Department of Biology, York College. Results. Methods. Introduction.
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The Depressive Behavior and Physiological Effects on CD-1 Female Mice (Mus musculus) Subjected to a Series of Chronic Unpredictable Stressors While on a High Flaxseed Oil Diet
Caitlin Verhalen, Department of Biology, York College
A. Physiological results:
24 CD-1 Female Mice
Flaxseed Oil Diet
Vegetable Oil Diet
GROUP I Vegetable Oil Diet
Flaxseed Oil Diet
B. Behavioral results:
Table1. Mean weights (grams) for CD-1 mice
Behavioral + Blood Tests on all 4 groups
1. Do popular claims about changing ones’ diet in
order to reduce depression hold true?
2. Would a diet with a higher quantity of essential
fatty acids, (EFA’s) like the rich source of Omega-3 in
flaxseeds be able to help reduce the cortisol/glucose
release as well as depressive behaviors in mammals?
Figure 1. Method for saturating pellets with oil.
Figure 1. Set up for the forced swim test in
2000mL flasks with distilled H20
Kumar, B., Kuhad., Chopra, K. 2011. Neuropsychopharmacological effect of sesamol
In unpredictable chronic mild stress model of depression: behavioral and
biochemical evidences. Psychopharmacology. 214: 819-828.
Tanna, I., Pandya, P., Harisha, C.R., Shukla, V.J., Chandola, H.M. 2013.
Pharmacognosticaland Phytochemical evaluation of Atasi (Linumusitatissimum L.)
Indian Journal of Traditional Knowledge. 12(4): 688-692.
Figure 2. Set up for the tail suspension test
in a 10 Liter glass tank separated by a
cardboard division. Tails supported by
tape hung from wooden rod on top of tank
Figure 3. Set up for the open field test. Field
was surrounded by lamps on each side.
I would like to thank Dr. Rehnberg for his guidance and feedback throughout my research. I
would also like to thank Joan Carpenter for supplying any necessary items needed for my research.
Additionally I would like to thank Raphael Perez for his help in handling the animals and assisting
with the behavioral tests.