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Non-Hodgkin’s Lymphoma

Non-Hodgkin’s Lymphoma. NHL is a heterogenous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment. It usually originates in the lymphoid tissues and can spread to other organs.

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Non-Hodgkin’s Lymphoma

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  1. Non-Hodgkin’s Lymphoma • NHL is a heterogenous group of lymphoproliferative malignancies with differing patterns of behavior and responses to treatment. • It usually originates in the lymphoid tissues and can spread to other organs. • Separated from Hodgkin’s disease by the recognition of the Reed-Sternberg cells. • However, unlike Hodgkin disease, NHL is much less predictable and has a far greater predilection to disseminate to extranodal sites.

  2. Non-Hodgkin ‘s Lymphoma • It can occur at any age and are often marked by lymph nodes that are larger than normal, fever, and weight loss. • There are many different types of non-Hodgkin lymphoma. • These types can be divided into: • Aggressive (fast-growing) types • Indolent (slow-growing) types • They can be formed from either B-cells or T-cells. • Most NHLs are of B-cell origin. • The prognosis depends on the histologic type, stage, and treatment.

  3. Indolent lymphomas Aggressive Lymphomas It has a shorter natural history, but a significant number of these patients can be cured with combination chemotherapy regimens. • Relatively good prognosis, with median survival time as long as 10 years, but they are not usually curable in advanced stages. • Early-stage (I and II) indolent NHL can be treated effectively with radiation therapy alone. • Most of the indolent types are nodular (or follicular) in morphology.

  4. B-cell non-Hodgkin lymphomas T-cell non-Hodgkin lymphomas Mycosis fungoides Anaplasticlarge cell lymphoma Precursor T-lymphoblastic lymphoma • Burkitt lymphoma • Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) • Diffuse large B-cell lymphoma • Follicular lymphoma • Immunoblasticlarge cell lymphoma • Precursor B-lymphoblastic lymphoma • Mantle cell lymphoma

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