Bioinstrumentation Curriculum Workshop
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Bioinstrumentation Curriculum Workshop Whitaker Foundation Biomedical Engineering Educational Summit December 9, 2000. Rebecca Richards-Kortum, PhD The University of Texas at Austin John G. Webster, PhD The University of Wisconsin. Goals: Bioinstrumentation Curriculum.

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Bioinstrumentation Curriculum WorkshopWhitaker Foundation Biomedical Engineering Educational SummitDecember 9, 2000

Rebecca Richards-Kortum, PhD

The University of Texas at Austin

John G. Webster, PhD

The University of Wisconsin


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Goals: Bioinstrumentation Curriculum

  • Discuss and Generate Consensus Report:

    • Current Status and Best Practices

    • Critical Incoming Knowledge Base Needed

    • Role of Experiential Learning

    • Intellectual Trends for the Future

    • Recommendations for Future Curriculum


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Whitaker Foundation Philosophy

  • A thorough understanding of life sciences, with life sciences a critical component of the curriculum.

    2. Mastery of advanced engineering tools/approaches.

    3. Familiarity with problems of making and interpreting quantitative measurements in living systems.

    4. The ability to use modeling techniques as a tool for integrating knowledge.

    5. The ability to formulate and solve problems with medical relevance, including the design of devices, systems, and processes to improve human health.


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Current Status: Courses at Top 12 Institutions






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CWRU EBME310: Biomedical Instrum.

  • Topics:

    • Biopotential Electrodes

    • Electrochemical Transducers of Biochemical Variables

    • Temperature Transducers

    • Measuring Flow

    • Mechanical Transducers

    • Optical Sensing

    • Imaging in Single Cells

    • Single Cell Electrophysiological Measurements

    • Piezoelectric Transducers and Instruments

    • Analytical Instruments for Biomaterials Research


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CWRU EBME360: Biomedical Instrum. Lab

  • Topics:

    • Body Surface Electrochemistry

    • Multi-electrode ECG

    • EMG Transduction

    • LED pulse Plethysmograph Circuit

    • Patch Lamp Technique

    • Ultrasound Image Formation


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CWRU EBME313: BME Lab I

  • Topics:

    • Errors and Error Analysis

    • Ethics

    • Computer Presentation

  • Lab (63% of grade) – choose three from:

    • 3D landmark coordinates from bi-orthogonal film x-rays

    • Ultrasound measurements of flow

    • Measuring neurotransmitters with microelectrode

    • Quantitative Properties of the Neuromuscular system

    • Evaluation of bone/implant interface using radiography

    • Patch clamp recording from retinal cells

    • Measurement of blood flow using PET

    • Compare mammographic image registration algos

    • Measuring the compliance of heart valves


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UCSD BE122B: Biomedical Electronics

  • Topics:

    • Analog to Digital Conversion

    • Digital Ckt Building Blocks

    • Convolution

    • Sampling Theorem

    • Fourier Transforms

    • Image Processing

    • Ultrasound

    • Computed Tomography

    • Electrokinetic Phenomena

  • Lab: No

  • Project: 25%


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UCSD BE 186B: Principles of Bioinst. Design

  • Topics:

    • Biopotentials

    • Electronics Review

    • Amplifiers

    • Electrical Safety

    • Biopotential Electrodes

    • Chemical Sensors

    • Light Based Instrumentation

    • Video Systems

    • Flow Measurements

    • Ultrasound

  • Lab: No

  • Project: No


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Duke 163L: BME Elec. and Meas. I

  • Topics:


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Duke BME164L: BME Elec. and Meas. II

  • Topics:

    • Transducers and Sensors

    • Op Amps, Filter, Differential and Instrument Amplifiers

    • Digital Devices and Circuits

    • Recording and Display Devices

    • Fourier Transforms, Series and Sampling

  • Lab (20% of grade)

  • Project (50% of grade)

    • Sensor, signal processing unit, A/D converter, Display


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Penn BE209: Bioengineering Lab I

  • Topics:

    • Biomedical Electronics

    • Mechanical Testing of Biological Specimens

  • Lab: (50% of grade)

    • Electronic thermometer

    • Building the electronic scale

    • Building the electronic exercise evaluation device

    • Building the electronic signal generator

    • Uniaxial Load testing of biological specimens

    • Tensile properties of chicken skin

    • Three point bending of chicken bones

    • Impact strength of chicken bone

  • Uses Discovery Learning


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Penn BE310: Bioengineering Lab IV

  • Topics:

    • Fluid Mechanics

    • Signal Analysis

  • Lab:

    • Fluid Mechanical Simulation of Coughing

    • Measurement of Pressure and Flow in Straight Tube

    • Steady Flow through a Sacular Aneurysm Model

    • Conservation of Energy - Thermodilution

    • Signal Analysis: The Electrocardiogram

    • Signal analysis: Vibration Analysis

  • Project:

    • Several weeks duration


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Wisconsin BME310: Bioinstrumentation

  • Topics:

    • Measurement systems

    • Signal Processing

    • Molecules in Clinical Chemistry

    • Mol. Measurements in Biomaterials and Tissue Eng.

    • Hematology

    • Cell. Measurements in Biomaterials and Tissue Eng.

    • Nervous System, Heart and Circulation, Lungs, Kidney, Bone and Skin

  • Labs (20% of grade):

    • 1. Blood Pressure, 2. Circuits, 3. Pressure Sensor, 4. Pulse Oximeter, 5. ECG, 6. Ultrasonic Flowmeter, 7. Spirometery, 8. Temperature, 9. Spectrophotometer, 10. Electrophoresis, 11. Dynamic Light Scattering, 12. Microscopes


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UT EE374k: Biomedical Instrumentation

  • Topics:

    • Transducers

    • Light sources, Photodetectors

    • Signal conditioning and amplification

    • Biopotentials

    • EMG, ECG

    • Electrodes

    • Microeelctrodes

    • Blood Pressure

    • Flow

    • Ultrasound

    • Pacemakers, Defribrillators

    • Electrical Safety




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Current Status: Exercise Number One

  • Introductions

  • Describe Bioinstrumentation Curriculum at Your Institution


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Best Practices

  • Issues to Consider:

    • Course Subject Matter

      • General Course Outcomes

      • Specific Course Learning Objectives

    • Course Outline

    • Prerequisites

    • Course Level

    • Textbooks

    • Laboratories


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Best Practices: Industrial Survey

  • Please list the 5 most important technical topics that a BME who graduates with a BS in the next 5-10 years will need to know.

  • 1. PSI, 2. Sulzer Carbomedics, 3. Sulzer Biologics, 4. Sulzer Orthopedics, 5. Sulzer Carbomedics, 6. GE, 7. Zeiss


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Company #: Top 5 Skills


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Course Subject Matter: Overall Goal

  • Prepare students to design and utilize biomedical instrumentation for measurements on humans and animals.

    • Sensors

    • Diagnostic Devices

    • Therapeutic Devices

    • New Fields: Molecular engineering, cell and tissue engineering, biotechnology


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General Course Outcomes

  • Recall bioinstrumentation vocabulary

  • Analyze measurement specifications

  • Choose the best method of making a measurement of performing therapy

  • Perform open-ended design of a measurement or therapeutic device

  • Analyze data resulting from a measurement of therapeutic device

  • Search internet, medical, engineering and patent databases

  • Communicate effectively

  • Pass nationally-normed subject content exams


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Specific Course Learning Objectives

  • Behaviorally observable objectives that illustrate concepts, relationships and skills to be gained

  • Examples:

    • Draw circuit / amplifier design for a pO2 electrode

    • Draw block diagrams for A-mode, B-mode and T-M ultrasonic image scanners

    • Design grounding system for an ICU

    • Explain how DNA is automatically sequenced and and how fluorescence assists signal processing


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Course Outline: Exercise #2

  • Rank the ten most important topics to cover



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Pre-requisites

  • Should include:

    • One year of calculus and physics

    • One semester of chemistry

    • Differential equations

    • Cell and molecular biology

    • Electric circuits

    • Electronics

    • Background in programming, statistics, signal analysis


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Course Level

  • Junior year





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Role of Experiential Learning

  • Knowledge taught in a single context is less likely to support flexible transfer of knowledge.

  • Laboratory modules:

    • Develop intuition and deepen understanding of concepts

    • Apply concepts learned in class to new situations

    • Experience basic phenomena

    • Develop critical, quantitative thinking

    • Develop experimental and data analysis skills

    • Learn to use scientific apparatus

    • Learn to estimate statistical errors, recognize systematic errors

    • Develop reporting skills

Science Teaching Reconsidered: A Handbook; National Research Council


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Laboratories

  • Exercise #3: Rank the top 5 most important laboratory experiences



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Role of Technology in Learning

  • Bring real world problems into classrooms

  • Provide scaffolding to augment what learners can do and reason about on their path to understanding

  • Increase opportunities for learners to receive feedback; to reflect on their learning process; to receive guidance toward progressive revisions that improve learning

  • Build local, global communities of teachers and learners

  • Expand opportunities for teacher learning

Bransford et al; How People Learn


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Web Based Instructional Materials

  • http://utwired.engr.utexas.edu

  • http://utwired.engr.utexas.edu/swpm/

  • http://www.utwired.engr.utexas.edu/ee302videos/


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ERC

  • NSF ERC: Bioengineering Educational Tech.

    • Modular, multimedia learning tools

    • Collaboration of bioengineering educators and learning scientists

    • $10 Million over 5 years

http:www.vanth.org


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Recommendations for Future Curriculum

  • Past: emphasized measurements in traditional areas such as biomedical instrumentation and imaging

  • Future: Expand these areas to include measurements in biosensors, molecular, cell and tissue engineering and biotechnology


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sour

bitter

salt

sour

sweet

The UT Electronic Taste Chip

salts, sugars, acids, alkaloids, small molecules, proteins, antibodies, DNA, redox species, solvents

John T. McDevitt / UT Chem. Biochem. Dept.



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Mass Production of Customized Chips

106 Beads per Gram

John T. McDevitt / UT Chem. Biochem. Dept.


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Science Demonstration #1

Ca(2+) Flow Dynamics Visualized (OCP Beads)

John T. McDevitt / UT Chem. Biochem. Dept.


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Science Demonstration #4

Beads conjugated to monoclonal antibody to HIV p24

Blank control beads

John T. McDevitt / UT Chem. Biochem. Dept.


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Areas for the Future: Exercise #5

  • What new areas of bioinstrumentation will be important to emphasize in the next 5 – 10 years?


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Questions for Discussion:

Should all BME students take a bioinstrumentation course?


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Questions for Discussion:

What role can technology-enhanced learning play in bioinstrumentation courses and laboratories?


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