MOVEMENT OF MELANOSOMES
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MOVEMENT OF MELANOSOMES. FORMATION OF MELANOSOMES. MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE). HUMAN SKIN. MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS. MELANOBLASTS DIVIDE TO FORM MELANOCYTES.

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MOVEMENT OF MELANOSOMES

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Movement of melanosomes

MOVEMENT OF MELANOSOMES


Movement of melanosomes

FORMATION OF MELANOSOMES


Movement of melanosomes

MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE)


Movement of melanosomes

HUMAN SKIN


Movement of melanosomes

MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS

MELANOBLASTS DIVIDE TO FORM MELANOCYTES


Movement of melanosomes

AN AUTO - IMMUNE DISEASE IN WHICH SOME MELANOCYTES ARE DESTROYED BY THE IMMUNE SYSTEM


Movement of melanosomes

MELANSOMES ARE TAKEN UP BY PHAGOCYTOSIS INTO THE LOWER KERATINOCYTES


Movement of melanosomes

INACTIVE TYROSINASE DUE TO MUTATION


Movement of melanosomes

MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.

BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.


Movement of melanosomes

CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE.

SO MISDIRECTED AT TRANS-GOLGI SYSTEM

MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.


Movement of melanosomes

LACK OF TYROSINE TRANSPORT SYTEM IN MELANOSOME MEMBRANE.


Movement of melanosomes

LACK OF FUNCTIONAL TYROSINASE


Movement of melanosomes

LACK OF TRANSFER TO KERATINOCYTES


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