MOVEMENT OF MELANOSOMES
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MOVEMENT OF MELANOSOMES. FORMATION OF MELANOSOMES. MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE). HUMAN SKIN. MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS. MELANOBLASTS DIVIDE TO FORM MELANOCYTES.

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MOVEMENT OF MELANOSOMES

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MOVEMENT OF MELANOSOMES


FORMATION OF MELANOSOMES


MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE)


HUMAN SKIN


MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS

MELANOBLASTS DIVIDE TO FORM MELANOCYTES


AN AUTO - IMMUNE DISEASE IN WHICH SOME MELANOCYTES ARE DESTROYED BY THE IMMUNE SYSTEM


MELANSOMES ARE TAKEN UP BY PHAGOCYTOSIS INTO THE LOWER KERATINOCYTES


INACTIVE TYROSINASE DUE TO MUTATION


MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.

BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.


CORRECT SUGARS ARE NOT ADDED TO OLIGOSACCHARIDES OF TYROSINASE.

SO MISDIRECTED AT TRANS-GOLGI SYSTEM

MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.


LACK OF TYROSINE TRANSPORT SYTEM IN MELANOSOME MEMBRANE.


LACK OF FUNCTIONAL TYROSINASE


LACK OF TRANSFER TO KERATINOCYTES


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