MOVEMENT OF MELANOSOMES. FORMATION OF MELANOSOMES. MELANOSOMES (GREEN) MICROTUBULES (RED) F-ACTIN (BLUE). HUMAN SKIN. MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS. MELANOBLASTS DIVIDE TO FORM MELANOCYTES.
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MELANOBLASTS MIGRATE FROM THE NEURAL CREST DURING EMBRYOGENESIS
MELANOBLASTS DIVIDE TO FORM MELANOCYTES
AN AUTO - IMMUNE DISEASE IN WHICH SOME MELANOCYTES ARE DESTROYED BY THE IMMUNE SYSTEM
MELANSOMES ARE TAKEN UP BY PHAGOCYTOSIS INTO THE LOWER KERATINOCYTES
INACTIVE TYROSINASE DUE TO MUTATION KERATINOCYTES
MUTATION CAUSING SOME IMPROPER FOLDING THAT DOES NOT AFFECT TYROSINASE ACTIVITY.
BUT GOLGI QUALITY CONTROL SENDS IT BACK TO THE RER.
SO MISDIRECTED AT TRANS-GOLGI SYSTEM
MAY BE PUT INTO SECRETORY VESICLES BY MISTAKE.
LACK OF FUNCTIONAL TYROSINASE TYROSINASE.
LACK OF TRANSFER TO KERATINOCYTES TYROSINASE.