Presentation On
This presentation is the property of its rightful owner.
Sponsored Links
1 / 21

Presentation On Non-Steroidal Anti-Inflammatory Drugs PowerPoint PPT Presentation


  • 190 Views
  • Uploaded on
  • Presentation posted in: General

Presentation On Non-Steroidal Anti-Inflammatory Drugs. Presented by: Mahwish Nasir. CELECOXIB DRUG CATEGORY : Coxib(cox-2-inhibitor). Next Drug. KETOROLAC TROMETHAMINE Nonselective Cox inhibitor DRUG CATEGORY : NSAID. Previous Drug.

Download Presentation

Presentation On Non-Steroidal Anti-Inflammatory Drugs

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


Presentation on non steroidal anti inflammatory drugs

Presentation On

Non-Steroidal Anti-Inflammatory Drugs

Presented by: Mahwish Nasir


Presentation on non steroidal anti inflammatory drugs

CELECOXIB

DRUG CATEGORY : Coxib(cox-2-inhibitor)

Next Drug


Presentation on non steroidal anti inflammatory drugs

  • KETOROLAC TROMETHAMINE

  • Nonselective Cox inhibitor

  • DRUG CATEGORY : NSAID

Previous Drug


Presentation on non steroidal anti inflammatory drugs

Celecoxib


Presentation on non steroidal anti inflammatory drugs

Main Menu

Celecoxib

DRUG DESCRIPTION:

Celecoxib is chemically designated as 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzene sulfonamide and is a diaryl-substituted pyrazole. It has the following chemical structure:

MECHANISM OF ACTION:

  • Celecoxib is a highly selective COX-2inhibitor , about 10 – 20 times more selective for COX -2 than for COX-1 .

  • COX-2 selective inhibitors , were developed in an attempt to inhibit prostacyclin synthesis.

  • It is done by COX-2 ISO enzyme Induced at sites of inflammation without affecting the action of the constitutively active “house keeping” COX-1 ISO enzyme found in the GI tract, kidneys, and platelets.

  • COX-2 inhibitors have analgesic, anti-pyretic, and anti-inflammatory effects similar to those of non-selective NSAIDs.

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

Celecoxib

INDICATIONS:

  • Rheumatoid arthritis

  • Osteoarthritis

    DOSAGE:

  • Osteoarthritis (adults): 200mg capsule once daily or in two divided doses.

  • Increase to 200mg twice daily if necessary. Maximum 400mg daily.

    CHILDREN: not recommended.

  • Rheumatoid arthritis (adults): 200 to 400mg daily.

  • CHILDERN: not recommended.

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

Celecoxib

PHARMACOLOGY:

  • Pharmacokinetics:

  • HALF-LIFE(hours): 11

  • URINARY EXCRETION: 27%

  • Pharmacodynamics:

  • The Coxib continue to be investigated to determine whether their effects on prostacyclin production could lead to a prothrombotic state.

  • It causes no more edema or renal effects than other members of NSAIDs group.

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

Celecoxib

CONTRA-INDICATION:

  • History of hypersensitivity to sulphonamides orNSAIDs.

  • Active peptic ulceration or GI bleeding.

  • Severe renal or hepatic impairment.

  • Severe congestive heart failure.

  • Safe-use during pregnancy or lactation is not advisable.

  • Precautions:

  • Risk of hypovolaemia in elderly patient ( > 65 yrs).

  • Left ventricular dysfunction.

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

Celecoxib

INTERACTIONS:

  • Diuretics

  • Anti-hypertensive

  • ACE inhibitors

  • Anti-coagulants

  • Lithium

  • Cyclosporine

  • Rifampicin

  • Barbiturates

  • Fluconazole

  • Methotrexate

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

Celecoxib

SIDE-EFFECTS:

  • Fluid retention

  • GI upset

  • Dizziness

  • Insomnia

  • Skin rash

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

Celecoxib

AVAILABLE BRANDS AND PRICES:

  • CELART(Hilton)

    Price:

  • Caps 100mg:10’s: 97.75

  • Caps 200mg:10’s: 148.75

  • CELBEXX (Getz-pharma)

    Price:

  • Caps: 100mg: 20’s :102.00

  • Caps: 200mg: 20’s: 170.00


Presentation on non steroidal anti inflammatory drugs

KETOROLAC TROMETHAMINE


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

Mechanism of action:

  • It is an NSAID promoted for systemic use.

  • It inhibits prostaglandin biosynthesis.

DRUG DESCRIPTION:

Ketorolac is potent analgesic but only a moderately effective anti-inflammatory drug. It is one of the few NSAIDs approved for Perenteral administration.

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

  • Indications:

  • Short -term management of moderate to severe post- operative pain.

  • Available dosage forms:

    Oral:

  • 10mg tablets

    Perenteral:

  • 10-30mg per ml for IM or Iv injection.

    Ophthalmic:

  • 0.5 % solution.

Continue


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

  • Dosage regimen:

    Adults:

  • Initially 10mg by IM or bolus IV daily for upto2 days.

  • Maximum 90mg daily for up to 2 days.

    Elderly:

  • Initially 10mg by IM or bolus Iv injection then 10-30mg every 4-6 hours.

  • Maximum 60mg daily for 2 days.

    Children:

  • Under 16 yrs, not recommended.

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

Contra-indication:

  • Peptic ulcer

  • GI or cerebrovascular bleeding

  • Coagulation disorders

  • Asthma

  • Renal impairment

  • Hypovolaemia during dehydration

    Pregnancy & Lactation:

  • Safe use during pregnancy and lactation is not advisable.

    ( NOTE: unless expected benefit outweighs potential risk.)

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

PHARMACOLOGY:

Pharmacokinetics:

  • HALF-LIFE(hours): 4-10

  • URINARY EXCRETION: 58%

    Pharmacodynamics:

  • The drug does appear to have significant analgesic efficacy and has been used successfully to replace morphine in some situations involving mild to moderate post surgical pain.

  • When used with an opioid, it may decrease the opioid requirement by 25 to 50%.

    Precautions:

  • Homeostasis

  • Allergic disease

  • Cardiac dysfunction

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

Interaction:

  • Anticoagulants

  • Lithium

  • Frusemide

  • Oxypentifylline

  • NSAIDs

  • Methotrexate

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

Side effects:

  • Abnormal liver function tests

  • Acute renal failure

  • Bronchospasm

  • Anaphylaxis

  • Pain at injection site

  • Ulcers

  • Wound hemorrhage

  • GI disturbances

  • Dizziness

Next


Presentation on non steroidal anti inflammatory drugs

Main Menu

KETOROLAC TROMETHAMINE

AVAILABLE BRANDS AND PRICES:

  • TORADOL(Roche)

    Price:

  • Inj 30mg :5×1ml : 455.50

  • TORAPAN (Duopharma)

    Price:

  • Inj 30mg :10×1ml : 589.68.

References


Refrences

Main Menu

REFRENCES:

  • Katzung

  • Pharma guide

  • Goodman Gilman


  • Login