Bischler napieralski reaction
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Bischler- Napieralski Reaction. Name: Sawsan Jaber Doctor: Fuad mahmmod. Table of Contents. 1. Objectives 2. Background 3. Reaction and mechanism 4. Application &recent literature 5. Conclusions 6. References. objective.

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Bischler- Napieralski Reaction

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Bischler napieralski reaction

Bischler-Napieralski Reaction

Name: Sawsan Jaber

Doctor: Fuad mahmmod


Table of contents

Table of Contents

1. Objectives

2. Background

3. Reaction and mechanism

4. Application &recent literature

5. Conclusions

6. References


Objective

objective

The object of this research is to know a new information about this reaction

And its application.


Background

BACKGROUND

  • IT is an intramolecularelectrophilic aromatic substitutionreaction thatallows for thecyclizationof β-arylethylamides or β-arylethylcarbamates.

  • It was first discovered in 1893 byAugust BischlerandBernard Napieralski.

  • in affiliation withBasleChemical Works and theUniversity of Zurich.

  • The reaction is most notably used in the synthesis of dihydroisoquinolines, which can be subsequentlydehydratedtoisoquinolines.


Reaction mechnism

REACTION & MECHNISM


Bischler napieralski reaction

  • the Bischler-Napieralski Reaction involves an initial dehydration step of the amide followed by a cyclization.

  • Then formed nitrilium salts upon mild heating, whereas the Bischler-Napieralski Reaction required elevated temperatures to form dihydroisoquinolines.

  • In the dehydration, reagents such as PCl5, POCl3, SOCl2, ZnCl2 can be used to promote loss of the carbonyl oxygen.


Application and recent literature

Application and recent literature

  • A Versatile Cyclodehydration Reaction for the Synthesis of Isoquinoline and β-Carboline Derivatives


Bischler napieralski reaction

this reactions allowed the production of substituted isoquinoline libraries. The generated dihydroisoquinolines and tetrahydroisoquinolines could be oxidized to their corresponding isoquinoline analogues.


Conclusion

conclusion

  • Finely we know that The Bischler–Napieralski reaction is an intramolecular electrophilic aromatic substitution reaction.

  • And we try to present its reactions.


References

References

  • http://www.organic-chemistry.org/namedreactions/claisen-condensation.shtm.

  • August Bischler, Bernard Napieralski (1893). "Zur Kenntniss einer neuen Isochinolinsynthese". Berichte der Deutschen Chemischen Gesellschaft26 (2): 1903.


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