Aldosterone action in the nephron
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aldosterone action in the nephron. recall our nephron diagram. need to add a new structure. juxtaglomerular cells JUX-ta-glo-MAR-you-lar. sense blood pressure like a collar wrap around afferent arteriole (the arteriole leading to the glomerulus). normal blood pressure.

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recall our nephron diagram...

need to add a new structure...


juxtaglomerular cells

JUX-ta-glo-MAR-you-lar

  • sense blood pressure

  • like a collar

  • wrap around afferent arteriole

  • (the arteriole leading to the glomerulus)


normal blood pressure

low blood pressure

high blood pressure

  • glomerulus works on PRESSURE

  • if blood pressure is too low, filtration won’t happen fast enough

  • urea will stay in the blood

  • blood will become toxic


blood pressure too low

JG cells release renin

renin activates angiotensin

Na+

angiotensin calls aldosterone

(from adrenal gland)

aldosterone causes increased Na+ reabsorption

blood volume and blood pressure increase

blood gets “saltier”

blood absorbs MORE WATER by osmosis


angiotensin

adrenal gland

renin

aldosterone

Na+

water enters blood by osmosis


  • JG cells sense blood pressure (stretch receptors). if BP is too low...

  • JG cells secrete renin

  • renin activates angiotensin

  • angiotensin calls aldosterone (from adrenal cortex)

  • aldosterone causes increased reabsorption of sodium in the DCT

  • increased Na+ causes increased osmosis of water into bloodstream

  • blood volume increases

  • blood pressure increases

  • GFR increases


blood pressure too low is too low...

JG cells release renin

renin activates angiotensin

Na+

angiotensin calls aldosterone

(from adrenal gland)

aldosterone causes increased Na+ reabsorption

blood volume and blood pressure increase

blood gets “saltier”

blood absorbs MORE WATER by osmosis


normal blood pressure is too low...

low blood pressure

high blood pressure

  • glomerulus works on PRESSURE

  • if blood pressure is too low, filtration won’t happen fast enough

  • urea will stay in the blood

  • blood will become toxic


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