The hopkins pain workgroup seeing pain more clearly
Download
1 / 10

The Hopkins Pain Workgroup “Seeing Pain More Clearly” - PowerPoint PPT Presentation


  • 61 Views
  • Uploaded on
  • Presentation posted in: General

The Hopkins Pain Workgroup “Seeing Pain More Clearly”. Optogentic and electrophysiological assay of pain fibers in skin (mice) : Michael Caterina , Xinzhong Dong ,Yun Guan, Paul Fuchs Genetically-visualized pain fibers (mice): Xinzhong Dong, Yun Guan, Srinivasa Raja

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha

Download Presentation

The Hopkins Pain Workgroup “Seeing Pain More Clearly”

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


The hopkins pain workgroup seeing pain more clearly
The Hopkins Pain Workgroup“Seeing Pain More Clearly”

Optogentic and electrophysiological assay of pain fibers in skin (mice): Michael Caterina, Xinzhong Dong ,Yun Guan, Paul Fuchs

Genetically-visualized pain fibers (mice): Xinzhong Dong, Yun Guan, Srinivasa Raja

Functional and molecular characterization of pain fibers in nonhuman primates: Xinzhong Dong, Joseph Mankowski, Matthias Ringkamp

Functional and molecular characterization of pain fibers in patients with painful peripheral neuropathy: Michael Caterina, Michael Polydefkis




Innervation of the cochlea analogous to skin
Innervation of the cochlea: analogous to skin?

Type I afferents, large myelinated axons,

95% of nerve, carry sound.

Type II afferents, small axons, 5% of nerve unmyelinated, carry ???.


The hopkins pain workgroup seeing pain more clearly

Type I neuron:

95% of afferents

Contacts single IHC

Type II neuron:

5% of afferents

Contact many OHCs

Cat Weisz

Berglund and Ryugo ,1987


Progress to date
Progress to date

  • Type II afferents poorly driven by OHCs – so would respond only to (very) LOUD sound

  • But, type II afferents also excited by ATP (involved in pain sensation in skin). ATP is released during acoustic trauma.

  • Do type II afferents carry ‘ear pain’? The jury is still out.


Hyperacusis tinnitus altered afferent balance
Hyperacusis, tinnitus: altered afferent balance?

Acoustic trauma

Type II afferents remain


Adapt fiber recording methods to excised skin to study transduction of pain
Adapt fiber recording methods to excised skinto study transduction of pain

Patapoutian et al. 2003,



ad
  • Login