The hopkins pain workgroup seeing pain more clearly
This presentation is the property of its rightful owner.
Sponsored Links
1 / 10

The Hopkins Pain Workgroup “Seeing Pain More Clearly” PowerPoint PPT Presentation


  • 49 Views
  • Uploaded on
  • Presentation posted in: General

The Hopkins Pain Workgroup “Seeing Pain More Clearly”. Optogentic and electrophysiological assay of pain fibers in skin (mice) : Michael Caterina , Xinzhong Dong ,Yun Guan, Paul Fuchs Genetically-visualized pain fibers (mice): Xinzhong Dong, Yun Guan, Srinivasa Raja

Download Presentation

The Hopkins Pain Workgroup “Seeing Pain More Clearly”

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


The Hopkins Pain Workgroup“Seeing Pain More Clearly”

Optogentic and electrophysiological assay of pain fibers in skin (mice): Michael Caterina, Xinzhong Dong ,Yun Guan, Paul Fuchs

Genetically-visualized pain fibers (mice): Xinzhong Dong, Yun Guan, Srinivasa Raja

Functional and molecular characterization of pain fibers in nonhuman primates: Xinzhong Dong, Joseph Mankowski, Matthias Ringkamp

Functional and molecular characterization of pain fibers in patients with painful peripheral neuropathy: Michael Caterina, Michael Polydefkis


Pain…


Pain in the (r)Ear


Innervation of the cochlea: analogous to skin?

Type I afferents, large myelinated axons,

95% of nerve, carry sound.

Type II afferents, small axons, 5% of nerve unmyelinated, carry ???.


Type I neuron:

95% of afferents

Contacts single IHC

Type II neuron:

5% of afferents

Contact many OHCs

Cat Weisz

Berglund and Ryugo ,1987


Progress to date

  • Type II afferents poorly driven by OHCs – so would respond only to (very) LOUD sound

  • But, type II afferents also excited by ATP (involved in pain sensation in skin). ATP is released during acoustic trauma.

  • Do type II afferents carry ‘ear pain’? The jury is still out.


Hyperacusis, tinnitus: altered afferent balance?

Acoustic trauma

Type II afferents remain


Adapt fiber recording methods to excised skinto study transduction of pain

Patapoutian et al. 2003,


The Hopkins Pain Workgroup


  • Login