The hopkins pain workgroup seeing pain more clearly
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The Hopkins Pain Workgroup “Seeing Pain More Clearly”. Optogentic and electrophysiological assay of pain fibers in skin (mice) : Michael Caterina , Xinzhong Dong ,Yun Guan, Paul Fuchs Genetically-visualized pain fibers (mice): Xinzhong Dong, Yun Guan, Srinivasa Raja

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The Hopkins Pain Workgroup “Seeing Pain More Clearly”

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The hopkins pain workgroup seeing pain more clearly

The Hopkins Pain Workgroup“Seeing Pain More Clearly”

Optogentic and electrophysiological assay of pain fibers in skin (mice): Michael Caterina, Xinzhong Dong ,Yun Guan, Paul Fuchs

Genetically-visualized pain fibers (mice): Xinzhong Dong, Yun Guan, Srinivasa Raja

Functional and molecular characterization of pain fibers in nonhuman primates: Xinzhong Dong, Joseph Mankowski, Matthias Ringkamp

Functional and molecular characterization of pain fibers in patients with painful peripheral neuropathy: Michael Caterina, Michael Polydefkis


The hopkins pain workgroup seeing pain more clearly

Pain…


Pain in the r ear

Pain in the (r)Ear


Innervation of the cochlea analogous to skin

Innervation of the cochlea: analogous to skin?

Type I afferents, large myelinated axons,

95% of nerve, carry sound.

Type II afferents, small axons, 5% of nerve unmyelinated, carry ???.


The hopkins pain workgroup seeing pain more clearly

Type I neuron:

95% of afferents

Contacts single IHC

Type II neuron:

5% of afferents

Contact many OHCs

Cat Weisz

Berglund and Ryugo ,1987


Progress to date

Progress to date

  • Type II afferents poorly driven by OHCs – so would respond only to (very) LOUD sound

  • But, type II afferents also excited by ATP (involved in pain sensation in skin). ATP is released during acoustic trauma.

  • Do type II afferents carry ‘ear pain’? The jury is still out.


Hyperacusis tinnitus altered afferent balance

Hyperacusis, tinnitus: altered afferent balance?

Acoustic trauma

Type II afferents remain


Adapt fiber recording methods to excised skin to study transduction of pain

Adapt fiber recording methods to excised skinto study transduction of pain

Patapoutian et al. 2003,


The hopkins pain workgroup

The Hopkins Pain Workgroup


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