Journal of Immunology 1998, 161: 4489-4492 Center for Pathology, Center of Immunology, Washington University School of Medicine, St.Louis, MO. Goal of Paper.
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1998, 161: 4489-4492
Center for Pathology, Center of Immunology, Washington University School of Medicine, St.Louis, MO
AKA: Type 1 or juvenile Diabetes
The non-obese diabetic NOD mouse is an inbred strain of type I, insulin dependent diabetes mellitus (IDDM). The NOD mouse was developed by the Shionogi Research Laboratories in Japan in 1974 from a cataract prone subline, CTS of an outbred ICR mouse (Makino S. et al., 1980, Kolb H, 1987, Tochino Y., 1987). In the sixth generation of inbreeding of the CTS strain, the NOD and NON mice were separated. The NOD strain was established in 1980 after 20 generations of inbreeding.http://www.m-b.dk/Datasheets/nod.htm
The Jackson Laboratory
Aspartic Acid (D)
TCR bearing cells from BDC2.5 SCID mice transfected into lethally irradiated transgenic mice with specificity to B-cell Ag
Allowed 8 wks for bone marrow to mature in deficient animals
Found that Large number of mature single positive CD4 T cells in F1, but none in BALB/c, as expected
Found same levels of mature CD4 T cells in PD, showing (+) selection by PD MHC-2
After 3 mo, none of the chimeric mice showed signs of Diabetes
Figure 5 lethally irradiated transgenic mice with specificity to