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Traditional Medicine and HIV Clinical Pharmacology: Implementation Research

Tsitsi G Monera, PhD Fellow UB-UZ Aids Training Program. Traditional Medicine and HIV Clinical Pharmacology: Implementation Research . Outline. Parirenyatwa Hospital OI clinic support group Support group – Researcher model Herb-drug clinical study.

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Traditional Medicine and HIV Clinical Pharmacology: Implementation Research

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  1. Tsitsi G Monera, PhD Fellow UB-UZ Aids Training Program Traditional Medicine and HIV Clinical Pharmacology: Implementation Research

  2. Outline • Parirenyatwa Hospital OI clinic support group • Support group – Researcher model • Herb-drug clinical study

  3. Parirenyatwa Hospital OI clinic support group • People with common interests and experiences • Safe space to share common concerns, verbalize emotions • Positive reinforcement, emotional support, hope • Learning environment –coping skills, self-help projects, treatment information

  4. Support group Researcher • model born out of the HIV-infected patients’ needs for comprehensive pharmacotherapy and the pharmacologists’ needs to explore pharmacotherapy issues in HIV-Infected patients • mutually beneficial collaboration between support group and researcher

  5. Prevalence of Use of Traditional Medical Systems

  6. Traditional Medicine

  7. Preliminary in vivo studies in animal models typically serve as a basis for clinical trials

  8. Effect of Moringa oleifera (Moringa, Drumstick, Horseradish tree)on the Pharmacokinetics of Efavirenz and Nevirapine in vivo.

  9. Ethical Considerations • To compare the steady-state pharmacokinetics of nevirapine and efavirenz in HIV-positive patients before and after supplementation with Moringa oleifera leaf powder • 5 challenging levels of ethical and regulatory approvals (JREC, HSIRB, BRTI- exemption) Medical Control Authority (MCAZ)and national ethics committee (MRCZ)

  10. Acknowledgements The program is sponsored by the UB-UZ AIDS International Training Research program funded by the Fogarty International Center.

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