...
This presentation is the property of its rightful owner.
Sponsored Links
1 / 21

Дизайн исследования PowerPoint PPT Presentation


  • 82 Views
  • Uploaded on
  • Presentation posted in: General

Результаты двухгодового курса терапии ламивудином у пациентов, ранее не ответивших на противовирусную терапию.

Download Presentation

Дизайн исследования

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -

Presentation Transcript


6976629

,


6976629

, II III 6 , HBeAg anti-He

HBeAg: HBeAg -, anti-HBe +, HBV DNA -

- 5

HBV DNA 7MEq/mL (Chiron)


6976629

, , :

:HBeAg, anti-HBe, HBsAg, anti-HBs, HBV DNA (Chiron)

24

Knodell , -


6976629

45 (14%)

324

236

46%

43 (13%)

YMDD

HBV 24

128

24

Schiff et al 2000


6976629

n = 236

()

41

82%

65%

19%

16%

HBeAg + / anti-HBe -

93%

692.5 (0.4 - 44870)

HBV DNA MEq/mL ()

AT x ()

1.8 (0.3 - 56)

Schiff et al 2000


Ymdd hbv

, 2 YMDD HBV , 500 /

236 YMDD HBV 24

YMDD HBV 60% 24

YMDD HBV


6976629

-YMDD HBV

YMDD HBV

24

(%)

10/14

14/22

4/8

(%)

4/106

4/61

0

Schiff et al 2000


6976629

-YMDD HBV

YMDD HBV

24

(%)

14/21

26/51

12/30

- (%)

1/24

7/55

6/31

Schiff et al 2000


6976629

:

  • 14/22 (64%) 4/106 (4%)

  • p=0.001 ( McNemars)

  • ( ) ,

    :

  • 26/51 (51%) 7/55 (13%)

  • p=0.011 (McNemars Test)


2 knodell 24

-YMDD HBV

YMDD HBV

(2 ) - Knodell 24

(%)

38/53

77/128

39/75

3/53

12/128

(%)

9/75

Schiff et al 2000


A t 2 ymdd hbv

AT 2- YMDD HBV

AT (x)

=


A t 24 ymdd hbv n 136

AT 24 YMDD HBV (n=136)

35% (47/136) ()

65% (89/136) ()

( = 1258)

( = 1155)


A t 24 ymdd hbv n 90

AT 24 YMDD HBV (n=90)

26% (24/90) ()

73% (66/90)

()

( = 1926)


Hbv dna 2 ymdd hbv

HBV DNA 2- YMDD HBV

HBV DNA (Chiron) MEq/mL

()


Hbv dna 24 ymdd hbv n 128

HBV DNA 24 YMDD HBV (n=128)

HBV DNA (MEq/mL)

24

24% (31/128)

()

76% (97/128) ()

( = 37740)

( = 26885)


Hbv dna 24 ymdd hbv n 77

HBV DNA 24 YMDD HBV (n=77)

HBV DNA (MEq/mL)

24

22% (17/77)

()

78% (60/77)

()

( = 44870)

( = 10425)


Hbeag

HBeAg ,

(%)

12

24

: n = 22/197 17/71 5/126 39/192 30/70 9/122


6976629

2-

  • YMDD HBV (37%) (29%)

  • (2%) YMDD HBV,

  • 3 ,

  • , 5/281 (<2%) , , 2 YMDD HBV

    SAE = Serious Adverse Event


6976629

-

  • 64% 24

  • 4%

  • 51%

  • 60% - 9%

  • YMDD HBV


6976629

-

  • AT HBV DNA YMDD HBV,

  • , HBeAg

  • YMDD HBV HBeAg, , YMDD HBV


6976629

  • , - .

  • , ( ) HBeAg .


  • Login