Notch signaling. Exocrine Transcription. Intestinal Transcription. Suc/Isom. Amylase. IFABP. Jagged1. Jagged2. Dll1. Gut. ?. Gut. Gut. MIST1. Wnt /b- cat. Cdx1. GATA4. ?. Notch1. Notch2. Cdx2. Gut. ?. Ptf1a. Hes1. nr5a2. ?. Core Endodermal program.
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Core Endodermal program
Endocrine fate Allocation
Via Sox17 or Mix?
Activin or nrf
mafA < =? >
Also involving most members of the core endodermal program
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Documented interaction, positive
Hyperlink, review on subject
Documented interaction, negative
Link demonstrated in Zebrafish
Documented interaction, not in pancreas
Link demonstrated in Xenopus Laevis
Hyperlink, description of targeted mutation of gene
Suggested interaction, not proven
Comment on auto-regulation arrows:
Green: The gene acts by a self-sustainable mechanism – intrinsic stability of network
Red: The gene may act by a threshold mechanism – intrinsic instability of network
Comment on targeted mutation links:
Studies of the genes by targeting mutations may have been performed by several independent groups, and several publications may exist regarding a particular gene. Furthermore, independent targeting may have been performed, as is the case for e.g. Pdx1, HB9, Ptf1a, NeuroD. Here, each link branches out only to one given study. Please consult the text for additional information to other references having provided information about the role of the gene in pancreatic development using a targeted mutation approach.
Regulatory interactions during pancreatic development, obtained from Jan Jensen. Barbara Davis Center for Childhood Diabetes, U. Colorado Health Sciences Center.