Nausea and Vomiting. James Hallenbeck, MD Director, Palliative Care Services, Palo Alto VAHCS, Stanford University. Understand the pathophysiology of nausea and vomiting Utilize the “VOMIT” acronym in identifying causes of nausea Select antiemetic therapy, based underlying physiology.
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James Hallenbeck, MD
Director, Palliative Care Services,
Palo Alto VAHCS, Stanford University
Utilize the “VOMIT” acronym in identifying causes of nausea
Select antiemetic therapy, based underlying physiologyObjectives
Rodents do not vomit!
But ferrets do!
So WHY do we have this disgusting problem?
What protects this guy from eating something poisonous?
Drug Dopamine 2 Musc. Chol. Histamine
Scopolamine >10,000 .08 >10,000
Promethazine 240 21 2.9
Prochlorperazine 15 2100 100
Chlorpromazine 25 130 28
Metoclopramide 270 >10,000 1,000
Haloperidol 4.2 >10,000 1,600
Potency: K1 (nanomolar)
The lower the number, the stronger this agent is
at blocking this receptor
Adapted from Perourka, Snyder
antihistiminic drugs will help!
No good evidence, rationale for using promethazine