The scandinavian sarcoma group 25 years jubilee meeting st petersburg may 4 7 2004
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The Scandinavian Sarcoma Group 25 Years´Jubilee Meeting St. Petersburg, May 4-7, 2004. www.ssg-org.net. Sarcoma tumor board. Orthopaedic surgeon. Surgeon: Plastic Head & Neck Neuro Thorax Abdominal. Cytologist Pathologist Cytogenetics X-ray diagnostician. Patient. Oncologist.

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Sarcoma tumor board l.jpg
Sarcoma tumor board

Orthopaedic

surgeon

Surgeon:

Plastic

Head & Neck

Neuro

Thorax

Abdominal

Cytologist

Pathologist

Cytogenetics

X-ray diagnostician

Patient

Oncologist

Treatment plan

Surgery Radiotherapy: Preoperative Chemotherapy: Neoadjuvant

Intraoperative Adjuvant

Postoperative Intra-arterial

Sequential Tumour necrosis factor a

Brachytherapy isolated limb perfusion

Hyperthermia

Follow-up during and after treatment

Centralized registration

www.ssg-org.net


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SSG Register

Chairman H. Bauer Stockholm

Coordinators K. Sundby Hall Oslo Ö. Berlin Gothenburg

P. Gustafson Lund

C. Trovik Bergen

R. Huuhtanen Helsinki

www.ssg-org.net



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Theses planed

LeiomyosarcomaC. Svarvar, Helsinki

LiposarcomaK. Engström, Gothenburg

ChondrosarcomaB. Widhe, Stockholm

OsteosarcomaC. Müller, Oslo

Quality of lifeL. H. Aksnes, Oslo

Skeletal metastasesB. H. Hansen, Århus

Radiation therapy and local recurrence in STSN. L. Jebsen, Bergen

www.ssg-org.net


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SSG I Adjuvant chemotherapy in STS 1981 – 86

SSG V Treatment program for STS 1986 –

SSG X Treatment of metastatic STS (VIG) 1991 – 97

SSG XII Metastasecetomy and CHT for lungmet. 1996 – 97 from STS. An EORTC/SSG randomized phase III study

SSG XIII Treatment protocol for adults with 1998 – high-risk STS in extremities and trunk wall

Soft Tissue Sarcoma

www.ssg-org.net


High risk sts ssg xiii doxorubicin ifosfamide l.jpg

1,0

,9

,8

,7

,6

,5

,4

,3

,2

,1

1

2

3

4

5

High-risk STS (SSG XIII)doxorubicin/ifosfamide

Overall survival

3

-

year OS: 77%

Years

Promising preliminary results but:

Biased patient selection

Short follow-up time

Overall vs metastases-free survival


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R

A

N

D

O

M

I

Z

E

Imatinib Follow-up

12 months 48 months

Imatinib Follow-up

36 months 24 months

Arm 1

Arm 2

SSG XVIII

Adjuvant study for high-risk GIST

Primary objective:

To investigate the recurrence-free survival in GIST patients with a high (>50%) risk of disease recurrence within the first 5 years following the diagnosis and treated with adjuvant imatinib mesylate either for 12 or 36 months.


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Osteosarcoma

SSG II Combination therapy in OS 1982 – 1990

SSG VIII Therapy of OS 1990 – 1998

ISG/SSG I An Italian-Scandinavian treatment and 1997 – 2000 research protocol for high-grade

osteosarcoma of the extremities

ISG/SSG II Treatment of metastatic and pelvic 1998 – 2003 osteosarcoma

SSG XIV A Scandinavian treatment research 2000 – 2004

protocol for extemity localized high-

grade osteosarcoma

Euroboss I A European treatment protocol for bone 2003 sarcoma in patients older than 40 years

Euramos I An American/European treatment protocol 2004 for OS in patients <40 years

www.ssg-org.net


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Euramos-1

A randomised trial of the

European and American Osteosarcoma Study Group


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EURAMOS 1

  • Euramos-1

  • 4 y anticipated accrual time (1400 pts). Covers a population >0.5 billion people

  • Objectives

  • Event-free survival

  • Overall survival

  • Short-term toxicity

  • Long-term toxicity

  • Quality-of-life

  • Euramos-1

  • Optimize the treatment of patients suffering from osteosarcoma.

  • Open for all patients with resectable high-grade osteosarcoma of the limbs or axial skeleton

  • The trial takes into account the strong prognostic value of tumor response to preoperative chemotherapy and divides patients accordingly


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Ewing´s sarcoma

SSG IV Combined modality therapy in EWS 1984 – 90

SSG IX Therapy of EWS 1990 – 99

ISG/SSG III ISG/SSG treatment protocol for 1999 non-metastatic EWS

ISG/SSG IV ISG/SSG treatment protocol for 1999

high-risk EWS

www.ssg-org.net


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Future directions

Cancer Registries

Biobanks

Translational Sarcoma Research

www.ssg-org.net


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