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Is HMB the key?. H M B. Tony Chao. Background info. Beta- hydroxy -beta- methylbutyrate (HMB) Discovered by Dr. Steven L Nissen , dept of animal science, Iowa St Univ Produced from Leucine and a - ketoisocaproate (KIC) via KIC- dioxygenase Synthesized in the body

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Is hmb the key

Is HMB the key?

H

M

B

Tony Chao


Background info

  • Beta-hydroxy-beta-methylbutyrate (HMB)

  • Discovered by Dr. Steven L Nissen, dept of animal science, Iowa St Univ

  • Produced from Leucine and a-ketoisocaproate (KIC) via KIC-dioxygenase

  • Synthesized in the body

  • Food sources: alfalfa sprouts, grapefruit, catfish, asparagus, avocado

  • Sold as supplement to increase muscle gains and fat loss


Rowlands & Thompson, 2009

What are the claims?

  • Act as anti-catabolic agent

    • Attenuate proteolysis via down regulation of proteolytic pathways

    • Mechanism unclear

  • Increase lean muscle mass  increase maximal strength

    • HMB  HMG-CoA, provide carbon source for cholesterol synthesis  muscle hypertrophy

  • Improve body composition

    • Increase fatty-acid oxidation

    • Mechanism unknown


Rowlands & Thompson, 2009


Rowlands & Thompson, 2009


Rowlands & Thompson, 2009


Rowlands & Thompson, 2009


Gallagher et al., 2000

Training adaptation may attenuate exercise induced muscle damage (Rowlands & Thompson, 2009)


Results

  • Increase strength

    • Trained – trivial

    • Untrained – small effect (lower body)

  • Increase muscle mass

    • Trivial

  • Increase fat loss

    • Trivial

  • Improved body composition

    • Trivial


Conclusion

  • May initially be beneficial to untrained men starting a strength training program

  • May be of little worth to highly trained men

  • Up to ½ HMB excreted in urine (Nissen & Abumrad, 1997)


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