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Is HMB the key?. H M B. Tony Chao. Background info. Beta- hydroxy -beta- methylbutyrate (HMB) Discovered by Dr. Steven L Nissen , dept of animal science, Iowa St Univ Produced from Leucine and a - ketoisocaproate (KIC) via KIC- dioxygenase Synthesized in the body

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is hmb the key

Is HMB the key?

H

M

B

Tony Chao

slide2

Background info

  • Beta-hydroxy-beta-methylbutyrate (HMB)
  • Discovered by Dr. Steven L Nissen, dept of animal science, Iowa St Univ
  • Produced from Leucine and a-ketoisocaproate (KIC) via KIC-dioxygenase
  • Synthesized in the body
  • Food sources: alfalfa sprouts, grapefruit, catfish, asparagus, avocado
  • Sold as supplement to increase muscle gains and fat loss
slide3

Rowlands & Thompson, 2009

What are the claims?

  • Act as anti-catabolic agent
    • Attenuate proteolysis via down regulation of proteolytic pathways
    • Mechanism unclear
  • Increase lean muscle mass  increase maximal strength
    • HMB  HMG-CoA, provide carbon source for cholesterol synthesis  muscle hypertrophy
  • Improve body composition
    • Increase fatty-acid oxidation
    • Mechanism unknown
slide8

Gallagher et al., 2000

Training adaptation may attenuate exercise induced muscle damage (Rowlands & Thompson, 2009)

slide9

Results

  • Increase strength
    • Trained – trivial
    • Untrained – small effect (lower body)
  • Increase muscle mass
    • Trivial
  • Increase fat loss
    • Trivial
  • Improved body composition
    • Trivial
slide10

Conclusion

  • May initially be beneficial to untrained men starting a strength training program
  • May be of little worth to highly trained men
  • Up to ½ HMB excreted in urine (Nissen & Abumrad, 1997)
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