Utilizing NeSSI™ for Analytical Applications. Dave Veltkamp* Brian Marquardt* Charlie Branham † *Center for Process Analytical Chemistry (CPAC) University of Washington, Seattle WA † Grad Student from Bart Kahr’s group in Chemistry, UW. CPAC Project Overview.
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*Center for Process Analytical Chemistry (CPAC)
University of Washington, Seattle WA
† Grad Student from Bart Kahr’s group in Chemistry, UW
Full spectrum response of the 0%, 10%, and 50% bubbler flow samples used to make the PLS model showing both the change in intensity and shift in peak maximum with changing benzene concentration.
* MFC #3 run at 5% FF rather than 50% FF
Benzene concentration (ppm) calculated from the weight loss experiment data as a function of bubbler flow rate (%FF N2)
electronic pressure regulators
pump ventASI microFAST GC™
Typically 2-3 minutes
Trap pre-purge time
Column cool-down time
Trap cool-down time
Trap preheat time
Trap cleanout time
Column separation time
Adjustable parameters that affect analysis – lots of tuning potential
Not very demanding chromatography – but convenient reference method
Note: MFC #2 offset by 90%FF, numbers on plot represent step hold time
CO2 setpoints inverted & offset for clarity
Note: Total flow = 250 sccm, volume of cell ~ 210 ml – so about 1-2 min exchange time (lag) seems about right