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Mechanisms of Disease Environmental/Nutritional/ Diseases of Infancy and Childhood June 17, 2003

Mechanisms of Disease Environmental/Nutritional/ Diseases of Infancy and Childhood June 17, 2003. Stephen L. Putthoff, D.O., FCAP Chairman, Department of Pathology and Anatomy. Table 10-3, pg. 409 Table 10-4, pg. 409. Don't smoke and tell your patients not to.

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Mechanisms of Disease Environmental/Nutritional/ Diseases of Infancy and Childhood June 17, 2003

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  1. Mechanisms of DiseaseEnvironmental/Nutritional/ Diseases of Infancy and ChildhoodJune 17, 2003 Stephen L. Putthoff, D.O., FCAP Chairman, Department of Pathology and Anatomy

  2. Table 10-3, pg. 409 Table 10-4, pg. 409

  3. Don't smoke and tell your patients not to. Don't smoke, and tell your patients not to

  4. How much do you drink? • Do you have an alcohol problem? It might be useful if you reflected upon it • Do you have any friends who youthink have, or may have a predilection for alcohol abuse – but they seem oblivious?

  5. Table and images, p. 411

  6. p413

  7. Common OTC agents • Acetaminophen • Aspirin

  8. Pollution • Outdoor • Indoor

  9. Industrial exposures • Volatile organics • Halogenated hydrocarbons • Plastics, rubber and polymers • Metals • Table 20-12, pg. 421 Table 10-11, p 419

  10. Effects of lead • Clinical manifestations?

  11. DDT Diazanon Malathion Nicotine Arsenic Paraquat Warfarin Strychnine Pesticides

  12. Natural Toxins Radiation Injury UV irradiation Physical Environment Wounding = E x 1/T x 1/A x k abrasion laceration contusion gunshot wounds characteristics, range, etc. entries exits

  13. Physical Injury [cont’d] Thermal injuries burns hyperthermia hypothermia Electrical injuries Atmospheric pressure injury

  14. Food and Nutrition • Nutritional deficiencies • Protein-energy malnutrition Kwashiorkor Marasmus Table 10-20, pg. 438

  15. Protein Energy Malnutrition

  16. Vitamin deficiencies • Fat soluble • Water soluble Table 10-21, pg. 440 Deficiency states vs. toxicity

  17. Vit. A vs. Vit. C vs Vit. D • A: Fig. 10-23, pg. 442 • Eye; xerophthalmia, etc. • D: Fig. 10-24, pg. 443 • rickets, osteomalacia • C: Fig. 10-30, pg. 451 • scurvy Others: beriberi, chelitis, pellagra, macrocytic anemia,acrodermatitis enteropathica,

  18. Diet • High protein/low carbohydrate • Low protein • High carbohydrate • Basic principle: eat less, exercise more

  19. Chemoprevention of cancer • ??????

  20. Congenital malformations Perinatal infections RDS-newborn Erythroblastosis fetalis PKU Galactosemia Cystic fibrosis SIDS Neuroblastoma Wilms tumor Diseases of Infancy and Childhood

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