Mechanisms of disease environmental nutritional diseases of infancy and childhood june 17 2003
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Mechanisms of Disease Environmental/Nutritional/ Diseases of Infancy and Childhood June 17, 2003. Stephen L. Putthoff, D.O., FCAP Chairman, Department of Pathology and Anatomy. Table 10-3, pg. 409 Table 10-4, pg. 409. Don't smoke and tell your patients not to.

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Mechanisms of disease environmental nutritional diseases of infancy and childhood june 17 2003

Mechanisms of DiseaseEnvironmental/Nutritional/ Diseases of Infancy and ChildhoodJune 17, 2003

Stephen L. Putthoff, D.O., FCAP

Chairman, Department of Pathology and Anatomy



Don't smoke and tell your patients not to.

Don't smoke, and tell your patients not to


How much do you drink
How much do you drink?

  • Do you have an alcohol problem? It might be useful if you reflected upon it

  • Do you have any friends who youthink have, or may have a predilection for alcohol abuse – but they seem oblivious?




Common otc agents
Common OTC agents

  • Acetaminophen

  • Aspirin


Pollution
Pollution

  • Outdoor

  • Indoor


Industrial exposures
Industrial exposures

  • Volatile organics

  • Halogenated hydrocarbons

  • Plastics, rubber and polymers

  • Metals

    • Table 20-12, pg. 421

Table 10-11, p 419


Effects of lead
Effects of lead

  • Clinical manifestations?


Pesticides

DDT

Diazanon

Malathion

Nicotine

Arsenic

Paraquat

Warfarin

Strychnine

Pesticides


Natural Toxins

Radiation Injury

UV irradiation

Physical Environment

Wounding = E x 1/T x 1/A x k

abrasion

laceration

contusion

gunshot wounds

characteristics, range, etc.

entries

exits


Physical injury cont d
Physical Injury [cont’d]

Thermal injuries

burns

hyperthermia

hypothermia

Electrical injuries

Atmospheric pressure injury


Food and nutrition
Food and Nutrition

  • Nutritional deficiencies

  • Protein-energy malnutrition

Kwashiorkor

Marasmus

Table 10-20, pg. 438



Vitamin deficiencies
Vitamin deficiencies

  • Fat soluble

  • Water soluble

Table 10-21, pg. 440

Deficiency states vs. toxicity


Vit a vs vit c vs vit d
Vit. A vs. Vit. C vs Vit. D

  • A: Fig. 10-23, pg. 442

    • Eye; xerophthalmia, etc.

  • D: Fig. 10-24, pg. 443

    • rickets, osteomalacia

  • C: Fig. 10-30, pg. 451

    • scurvy

Others: beriberi, chelitis, pellagra, macrocytic anemia,acrodermatitis enteropathica,


Diet

  • High protein/low carbohydrate

  • Low protein

  • High carbohydrate

  • Basic principle: eat less, exercise more



Diseases of infancy and childhood

Congenital malformations

Perinatal infections

RDS-newborn

Erythroblastosis

fetalis

PKU

Galactosemia

Cystic fibrosis

SIDS

Neuroblastoma

Wilms tumor

Diseases of Infancy and Childhood


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