Mechanisms of disease environmental nutritional diseases of infancy and childhood june 17 2003
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Mechanisms of Disease Environmental/Nutritional/ Diseases of Infancy and Childhood June 17, 2003. Stephen L. Putthoff, D.O., FCAP Chairman, Department of Pathology and Anatomy. Table 10-3, pg. 409 Table 10-4, pg. 409. Don't smoke and tell your patients not to.

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Mechanisms of Disease Environmental/Nutritional/ Diseases of Infancy and Childhood June 17, 2003

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Mechanisms of DiseaseEnvironmental/Nutritional/ Diseases of Infancy and ChildhoodJune 17, 2003

Stephen L. Putthoff, D.O., FCAP

Chairman, Department of Pathology and Anatomy


Table 10-3, pg. 409 Table 10-4, pg. 409


Don't smoke and tell your patients not to.

Don't smoke, and tell your patients not to


How much do you drink?

  • Do you have an alcohol problem? It might be useful if you reflected upon it

  • Do you have any friends who youthink have, or may have a predilection for alcohol abuse – but they seem oblivious?


Table and images, p. 411


p413


Common OTC agents

  • Acetaminophen

  • Aspirin


Pollution

  • Outdoor

  • Indoor


Industrial exposures

  • Volatile organics

  • Halogenated hydrocarbons

  • Plastics, rubber and polymers

  • Metals

    • Table 20-12, pg. 421

Table 10-11, p 419


Effects of lead

  • Clinical manifestations?


DDT

Diazanon

Malathion

Nicotine

Arsenic

Paraquat

Warfarin

Strychnine

Pesticides


Natural Toxins

Radiation Injury

UV irradiation

Physical Environment

Wounding = E x 1/T x 1/A x k

abrasion

laceration

contusion

gunshot wounds

characteristics, range, etc.

entries

exits


Physical Injury [cont’d]

Thermal injuries

burns

hyperthermia

hypothermia

Electrical injuries

Atmospheric pressure injury


Food and Nutrition

  • Nutritional deficiencies

  • Protein-energy malnutrition

Kwashiorkor

Marasmus

Table 10-20, pg. 438


Protein Energy Malnutrition


Vitamin deficiencies

  • Fat soluble

  • Water soluble

Table 10-21, pg. 440

Deficiency states vs. toxicity


Vit. A vs. Vit. C vs Vit. D

  • A: Fig. 10-23, pg. 442

    • Eye; xerophthalmia, etc.

  • D: Fig. 10-24, pg. 443

    • rickets, osteomalacia

  • C: Fig. 10-30, pg. 451

    • scurvy

Others: beriberi, chelitis, pellagra, macrocytic anemia,acrodermatitis enteropathica,


Diet

  • High protein/low carbohydrate

  • Low protein

  • High carbohydrate

  • Basic principle: eat less, exercise more


Chemoprevention of cancer

  • ??????


Congenital malformations

Perinatal infections

RDS-newborn

Erythroblastosis

fetalis

PKU

Galactosemia

Cystic fibrosis

SIDS

Neuroblastoma

Wilms tumor

Diseases of Infancy and Childhood


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