Cellular Energy – The Krebs cycle. aka TCA -- Tricarboxylic Acid Cycle aka CAC -- Citric Acid Cycle. H 2 O. CO 2. CO 2. CO 2. acetyl-CoA. Kreb’s Cycle. citrate. pyruvate from glycolysis. NADH. oxaloacetate. isocitrate. malate. NADH. a- keto glutarate. fumarate. FADH 2.
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Cellular Energy – The Krebs cycle
aka TCA -- Tricarboxylic Acid Cycle
aka CAC -- Citric Acid Cycle
pyruvate from glycolysis
ADP --> ATP
ADP is phosphorylated to ATP. High-energy bond is formed.
(in this case a GDP -->GTP happens first, which immediately phosphorylates an ADP)
Water is added to a molecule.
Carbon dioxide is removed from a molecule.
NAD+ is reduced to NADH + H+ (aka NADH2 or NADre)
NAD has accepted a high-energy electron -- it will hold the energy until needed in another part of the cycle.
(Nicotinamide adenine dinucleotide)
FAD+ is reduced to FADH + H+ (aka FADH2 or FADre)
similar in function to NAD
(Flavin adenine dinucleotide)
Citrate -- SIT-rate -- 6 carbon
Isocitrate -- I-so-sit-rate -- 6 carbon
a-ketoglutarate -- AL-fa-KEY-to-GLU-ter-ate -- 5 carbon
Succinyl-CoA -- SUX-in-ul KO-a -- 4 carbon
Succinate -- SUX-in-ate -- 4 carbon
Fumarate -- FYUM-ar-ate -- 4 carbon
Malate -- MAL-ate -- 4 carbon
Oxaloactetate -- ok-SAL-o-ASS-uh-tate -- 4 carbon
Acetyl-CoA -- ah-SEET-ul KO-a -- 2 carbon
3 reductions of NAD+ to NADH
2 CO2 molecules given off
for EACH PYRUVIC ACID that enters the Kreb’s cycle-- therefore DOUBLE that for each GLUCOSE
1 FAD+ reduced to FADH2
1 ATP molecule (from GTP)
1 molecule of H2O added (net)