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Vaccines: Historical Perspective

Vaccines: Historical Perspective.  Immunity - state of protection from an infectious disease.  430 BC – Greek historian Thucydides - Athenian plague  15 th century – Chinese attempts to induce immunity  1718 – Mary Wortley Montagu – innoculated her children

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Vaccines: Historical Perspective

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  1. Vaccines: Historical Perspective Immunity - state of protection from an infectious disease. 430 BC – Greek historian Thucydides - Athenian plague 15th century – Chinese attempts to induce immunity 1718 – Mary Wortley Montagu – innoculated her children 1798 – Edward Jenner – milkmaids and cowpox/smallpox

  2. Vaccines: Historical Perspective Louis Pasteur early 1880’s – Cholera and chickens Attenuation hypothesis 1881 – Testing the hypothesis with anthrax and sheep 1885 – Rabies vaccine

  3. Vaccines Immunization – the process of producing a state of immunity in a subject. Vaccination – intentional administration of a harmless or less harmful form of a pathogen to induce a specific immune response that protects the individual against late exposure to the pathogen.

  4. Vaccines Passive immunity adaptive immunity conferred by the transfer of immune products, such as antibody or sensitized T cells, from an immune individual to a non-immune one. Natural maternal antibody Immune globulin Humanized monoclonal antibody Antitoxin

  5. Vaccines Active immunity – adaptive immunity that is induced by a natural exposure to a pathogen or by vaccination.  Natural infection  Vaccines  Toxoid

  6. Vaccines Types of vaccines: Live attenuated Inactivated Subunit Conjugate DNA Recombinant

  7. Vaccines Multivalent Conjugate

  8. Vaccines Multivalent Conjugate

  9. Vaccines DNA Vaccines

  10. Vaccines Recombinant Vector Vaccines

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