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Power of Endorphins by Placebo effect

Power of Endorphins by Placebo effect. Group 3. HOPE vs. EPOH group. HOPE group: 74% of patients responded to the drugs EPOH group: only 22% of patients responded to the same drugs

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Power of Endorphins by Placebo effect

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  1. Power of Endorphins by Placebo effect Group 3

  2. HOPE vs. EPOH group HOPE group: 74% of patients responded to the drugs EPOH group: only 22% of patients responded to the same drugs  ONLY difference between HOPE and EPOH group was the name of the drugs.

  3. Mesmerism • Wakeful state of focused belief.Heightened relaxation and suggestibility, connecting each other through magnetic fluid.  In the movie, with Mesmer’s therapeutic method, patients actually experienced easing of pain and decreasing symptoms.

  4. Placebo effect HOPE vs. EPOH case Mesmer's therapeutic method can be almost explained by ‘placebo effect’.

  5. Placebo effect Placebo means it is a substance with no specific therapeutic activity. Placebo effect occurs when a patient's symptoms are altered in some way by a treatment, due to the individual’s psychological expectation suggestion from an authority figure believingthat it will work.

  6. Placebo effect name of drug doctor’s confidence Placebo effect is influenced by context Image from Di Blasi Z, et al. “Influence of context effects on health outcomes: a systematic review.” 2001. Lancet 357:757-62.

  7. Placebo effect Placebo means ‘I will please’ , which indicates that the drug was given to make the patient happy, which would somehow make him better. • Placebo effect is in the patient, not the doctor

  8. Nocebo effects • Due to the subject's pessimistic belief and expectation that the inert drug would produce harmful results. (even though these responses had not been chemically generated.)

  9. Steps of placebo effect Trusting the doctor Expectationand Belief Pain Anxiety Symptoms would be decreased Biologicalprocess

  10. Biological process • Endorphins • chemical compounds that occur naturally in the brain and have similar pain-relieving properties to morphine, thought to be involved in the control of emotional responses.

  11. Physiological aspect (PAG) Injection of placebo Secretion of endogenous opioid Activation of opiate receptors Reduction of pain Psychological aspect Morphine injected : 70% Placebo injected : 35% Placebo effect in pain control Injection of Naloxone (opiate antagonist)

  12. Biological process • The study conducted at the University of Michigan provided the first direct evidence that the brain’s own pain-relieving chemicals, endorphins, play a role in the placebo effect.

  13. Biological process placebo

  14. In summary Expectation and belief by patient him/herself (HOPE group, Mesmer’s method, Placebo effect) Elicit biological process (Secretion of Endorphin, etc.) Symptoms, pain are eased

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