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Holiday Concerts: Whatcom Chorale Sunday, Dec. 12 3pm and 7:30 pm First Congregational Church Handel\'s Messiah. Bellingham Chamber Chorus Friday, December 10 8 pm PAC Concert Hall Bach Magnificat and a bunch of modern stuff. Upcoming Biochemistry Seminars. M November 29 4 pm SL 130.

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Presentation Transcript
slide1

Holiday Concerts:

Whatcom Chorale

Sunday, Dec. 12

3pm and 7:30 pm

First Congregational Church

Handel\'s Messiah

slide2

Bellingham Chamber Chorus

Friday, December 10

8 pm PAC Concert Hall

Bach Magnificat

and a bunch of modern stuff.

slide3

Upcoming Biochemistry Seminars

M November 29 4 pm SL 130

F December 3 4 pm SL 130

Structure, Function and Engineering of the Homing Endonuclease I-CreI

Extra Credit!!!!

slide4

Figure 15-20cX-Ray structure of bovine trypsin. (c) A drawing showing the surface of trypsin (blue) superimposed on its polypeptide backbone (purple).

Page 519

slide7

Example of

“convergent”

evolution.

slide8
Figure 15-22 Relative positions of the active site residues in subtilisin, chymotrypsin, serine carboxypeptidase II, and ClpP protease.

Page 521

slide11

General base

Electrostatic

stabilization

Rate determining step

(Michaelis

complex)

Scissile bond

slide13

Water replaces new

N terminal

Now the whole process operates in reverse:

slide14

Stable acyl-enzyme intermediate

Attacking nucleophile?

Leaving group?

figure 15 25a transition state stabilization in the serine proteases a the michaelis complex
Figure 15-25a Transition state stabilization in the serine proteases. (a) The Michaelis complex.

Page 524

figure 15 25b transition state stabilization in the serine proteases b the tetrahedral intermediate
Figure 15-25b Transition state stabilization in the serine proteases. (b) The tetrahedral intermediate.

Page 524

slide17
Figure 15-26a X-Ray structures of porcine pancreatic elastase in complex with the heptapeptide BCM7 (YPFVEPI). (a) The complex at pH 5.

Page 525

slide18
Figure 15-26b X-Ray structures of porcine pancreatic elastase in complex with the heptapeptide BCM7 (YPFVEPI). (b) The complex at pH 9.

Page 525

slide19

Stryer Fig. 9.16 Site directed mutagenesis of

subtilisin. Note the log scale. Mutations in the

catalytic triad lead to a dramatic loss of activity

slide22

Substrate

activation

schemes

Stryer Fig. 9.17 an 18

figure 15 8 the alternating nag nam polysaccharide component of bacterial cell walls
Figure 15-8 The alternating NAG–NAM polysaccharide component of bacterial cell walls.

Page 507

slide27

C16 and C18 most common

*

*usually. Bacteria have some odd number chains

slide28

Rarely

conjugated

rare

slide37

Glycerolphospholipids

See Table 12-2

slide41

Figures 12-4, 12-6

and 12-7

ganglioside

slide42

GM2:sphingosine linked to 4 sugars

Tay-Sachs Disease: GM2 degradation enzyme missing

slide48

membrane fluidity is affected by temperature

above transition temp.

below transition temp.

See Table 12-1

fluid mosaic model of membranes
Fluid Mosaic model of membranes
  • membrane is 2-D fluid lipid matrix in which proteins are imbedded
  • proteins (and lipids) are free to diffuse laterally but not transversely (i.e. they can’t “flip” from one side of bilayer to the other)
  • proteins that don’t migrate freely are bound to an anchoring “skeleton”
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