Holiday Concerts: Whatcom Chorale Sunday, Dec. 12 3pm and 7:30 pm First Congregational Church Handel's Messiah. Bellingham Chamber Chorus Friday, December 10 8 pm PAC Concert Hall Bach Magnificat and a bunch of modern stuff. Upcoming Biochemistry Seminars. M November 29 4 pm SL 130.
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Sunday, Dec. 12
3pm and 7:30 pm
First Congregational Church
Bellingham Chamber Chorus
Friday, December 10
8 pm PAC Concert Hall
and a bunch of modern stuff.
Upcoming Biochemistry Seminars
M November 29 4 pm SL 130
F December 3 4 pm SL 130
Structure, Function and Engineering of the Homing Endonuclease I-CreI
Figure 15-20cX-Ray structure of bovine trypsin. (c) A drawing showing the surface of trypsin (blue) superimposed on its polypeptide backbone (purple).
Rate determining step
General base catalysis
Water replaces new
Now the whole process operates in reverse:
Stable acyl-enzyme intermediate
Stryer Fig. 9.16 Site directed mutagenesis of
subtilisin. Note the log scale. Mutations in the
catalytic triad lead to a dramatic loss of activity
Stryer Fig. 9.17 an 18
Chapter 12: Lipids and Membranes
C16 and C18 most common
*usually. Bacteria have some odd number chains
Figures 12-1 and
Much more reduced than CHO or protein-->high energy storage.
See Table 12-2
Table 12-2 Classes of Phospholipids
Figures 12-4, 12-6
GM2:sphingosine linked to 4 sugars
Tay-Sachs Disease: GM2 degradation enzyme missing
membrane fluidity is affected by temperature
above transition temp.
below transition temp.
See Table 12-1
Table 12-4: Compositions of some membranes
Figure 12-32 Freeze fracture