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Holiday Concerts: Whatcom Chorale Sunday, Dec. 12 3pm and 7:30 pm First Congregational Church PowerPoint PPT Presentation


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Holiday Concerts: Whatcom Chorale Sunday, Dec. 12 3pm and 7:30 pm First Congregational Church Handel's Messiah. Bellingham Chamber Chorus Friday, December 10 8 pm PAC Concert Hall Bach Magnificat and a bunch of modern stuff. Upcoming Biochemistry Seminars. M November 29 4 pm SL 130.

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Holiday Concerts: Whatcom Chorale Sunday, Dec. 12 3pm and 7:30 pm First Congregational Church

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Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Holiday Concerts:

Whatcom Chorale

Sunday, Dec. 12

3pm and 7:30 pm

First Congregational Church

Handel's Messiah


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Bellingham Chamber Chorus

Friday, December 10

8 pm PAC Concert Hall

Bach Magnificat

and a bunch of modern stuff.


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Upcoming Biochemistry Seminars

M November 29 4 pm SL 130

F December 3 4 pm SL 130

Structure, Function and Engineering of the Homing Endonuclease I-CreI

Extra Credit!!!!


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 15-20cX-Ray structure of bovine trypsin. (c) A drawing showing the surface of trypsin (blue) superimposed on its polypeptide backbone (purple).

Page 519


Table 15 4 a selection of serine proteases

Table 15-4A Selection of Serine Proteases.

Page 516


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Example of

“convergent”

evolution.


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 15-22 Relative positions of the active site residues in subtilisin, chymotrypsin, serine carboxypeptidase II, and ClpP protease.

Page 521


Figure 15 21 the active site residues of chymotrypsin

Figure 15-21The active site residues of chymotrypsin.

Page 520


Figure 15 23 catalytic mechanism of the serine proteases

Figure 15-23 Catalytic mechanism ofthe serine proteases.

Page 522


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

General base

Electrostatic

stabilization

Rate determining step

(Michaelis

complex)

Scissile bond


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

General base catalysis

decomposition


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Water replaces new

N terminal

Now the whole process operates in reverse:


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Stable acyl-enzyme intermediate

Attacking nucleophile?

Leaving group?


Figure 15 25a transition state stabilization in the serine proteases a the michaelis complex

Figure 15-25aTransition state stabilization in the serine proteases. (a) The Michaelis complex.

Page 524


Figure 15 25b transition state stabilization in the serine proteases b the tetrahedral intermediate

Figure 15-25bTransition state stabilization in the serine proteases. (b) The tetrahedral intermediate.

Page 524


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 15-26aX-Ray structures of porcine pancreatic elastase in complex with the heptapeptide BCM7 (YPFVEPI). (a) The complex at pH 5.

Page 525


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 15-26bX-Ray structures of porcine pancreatic elastase in complex with the heptapeptide BCM7 (YPFVEPI). (b) The complex at pH 9.

Page 525


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Stryer Fig. 9.16 Site directed mutagenesis of

subtilisin. Note the log scale. Mutations in the

catalytic triad lead to a dramatic loss of activity


Figure 15 27 activation of trypsinogen to form trypsin

Figure 15-27Activation of trypsinogen to form trypsin.

Page 527


Figure 15 28 activation of chymotrypsinogen by proteolytic cleavage

Figure 15-28Activation of chymotrypsinogen by proteolytic cleavage.

Page 528


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Substrate

activation

schemes

Stryer Fig. 9.17 an 18


Figure 15 8 the alternating nag nam polysaccharide component of bacterial cell walls

Figure 15-8The alternating NAG–NAM polysaccharide component of bacterial cell walls.

Page 507


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Chapter 12: Lipids and Membranes


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

C16 and C18 most common

*

*usually. Bacteria have some odd number chains


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Rarely

conjugated

rare


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figures 12-1 and

12-9


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Lipid structures


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Much more reduced than CHO or protein-->high energy storage.


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Glycerolphospholipids

See Table 12-2


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Table 12-2 Classes of Phospholipids


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figures 12-4, 12-6

and 12-7

ganglioside


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

GM2:sphingosine linked to 4 sugars

Tay-Sachs Disease: GM2 degradation enzyme missing


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-9


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-12


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

membrane fluidity is affected by temperature

above transition temp.

below transition temp.

See Table 12-1


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-16


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-14


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-31


Fluid mosaic model of membranes

Fluid Mosaic model of membranes

  • membrane is 2-D fluid lipid matrix in which proteins are imbedded

  • proteins (and lipids) are free to diffuse laterally but not transversely (i.e. they can’t “flip” from one side of bilayer to the other)

  • proteins that don’t migrate freely are bound to an anchoring “skeleton”


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Table 12-4: Compositions of some membranes


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-32 Freeze fracture


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-35


Holiday concerts whatcom chorale sunday dec 12 3pm and 7 30 pm first congregational church

Figure 12-20


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