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风湿病的常用免疫学检查 及临床应用 PowerPoint PPT Presentation


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风湿病的常用免疫学检查 及临床应用. 概 述. 多数风湿病的发病机制都与免疫失调有关, 因此检测自身抗体(抗细胞内、细胞表面和细胞外抗原的免疫球蛋白。)、补体、 淋巴细胞及其它免疫学成份有助于许多疾病的诊断、治疗和疗效判断。 对检验结果的判断必须密切结合临床,并进行综合分析。. 抗核抗体 (ANA ). 是指抗细胞核成分的抗体,换言之是指一组对细胞核内 DNA 、 RNA 、蛋白质、或这些物质的分子复合物的自身抗体。. 一、核的组成及其抗原性. 细胞核是由核膜、核仁、染色质和核液组成。

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风湿病的常用免疫学检查 及临床应用

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(ANA

  • DNA RNA


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  • U3ThRNA s PM-SclKuPCNA

  • DNA


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  • 1954HargraveSLE LE, , DNA-(DNP)DNPLE SLE50-85RA 10 PSSPM/DM


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  • HDNASLE,

  • S ENACTD

  • P DNASLE

  • C DNACREST

  • N 4-6sRNAPSS

  • ANA


Hep 2

Hep-2

  • SLE PSS

  • HEP-2 95 70

  • 85 50


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  • 1ds-DNA

    FarrRIA 20 30 SLE

    TE 15 110 SLE


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ds-DNASLE

40-60SLEds-DNA

,SLE


2 histon

2Histon

ELISA

  • 95

  • SLE 5070 PM/DM 13

  • RA 23 INH 53

  • SS 30 20

  • PSS 27 18


3 ena

3ENA

ENA

  • -SM-J0-1John

  • -RNPnRNA-PM-1polymyositis

  • -SS-A -Scl-70sclerederma

  • -SS-B


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Sm

  • SLE25SLE SLESLE


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nRNP

  • nRNP dsDNAMETD100


Ss a ro

SS-A/Ro

  • SS70-80SLE 40RA 20ANASS-A 60KD 52KD 60KDSLESSSS-A


Ss b la

SS-B/La

  • SS50-60SLE 10SS-BSS


Rib ribosome rnp

RIBribosome RNP)

  • SLE24SLE 1~2RIPLNNP, RIPSLE37%NPRIPSLE16%NP


Pcna proliferating cell nuclear antigen

PCNA(proliferating cell nuclear antigen)

  • 36KdDNA SLE2-10),


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Pm-1

  • PM/DM 8-15(+) , PSS3(+)PMPSS80%


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Jo-1

  • PM25-30) 60%PMJo-1Jo-1


Scl 70

Scl-70

  • PSS30~40) PSS Scl-70PSSScl-7010


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Ku

  • SLE, MCTD, PSS30-50DM5


Ki mi 2

KiMi-2

  • KiSLE8-20,

  • Mi-2PM5


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RA33

  • RA36%+RA RA338~24RAu1RNPRA33 RA33 1989Hassfeld


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RNP,Sm


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  • AdsDNA SLE

  • A-sm SLE

  • A-scl-70 PSS

  • A-Centromere CREST

  • A-Jo-1 PM

  • A-Pm-1 PM/DM

  • A-SSB SS

  • A-SSA SS. SLE

  • A-RNP MCTD. CTD

  • A-P SLE


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APL)

  • (AcL)IgGIgMIgA IgGIgAAclHLADRDQC4SLEAcL3344ELISASLE80 90 PSSRASSMCTD23151014AcL APS1957Conley


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AECA

  • SLE14-85 RAMCTDSSWegener's Behcet'skawasakiIgGIgMAECA AECAAECA


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(ANCA)

  • ANCA ANCA(cANCA)ANCA(pANCA)cANCAPR 3 -protlinasepANCAHyploperoxidase,MPO)cANCA90 cANCApANCAcANCAChurg-sttrauss

  • ANCA


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(RF)

  • RFIgGFCIgG IgG IgM-RFIgG-RFIgA-RF


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  • RF(IgM)RA 80RFRAELISAIgGIgARF 5RF RF


Lymphocyte typy

(lymphocyte typy)

  • TBBT


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  • TB TB


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TB

  • CD1 21/48 T

  • CD3 20/20/25 T SLERA

  • CD4 55 T

  • CD8 30/45 /T SLE

  • CD25 50-55 IL-2

  • CD45RO 80 T RA

  • CD19 95 B

  • CD21 140 B

  • CD22 135 B,T


Cytokine

(cytokine)

  • / T IL1-15IF2IL1IL6TNF


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  • IL-1 T IL-2

  • IL-2 THS IgG

    NKTB

  • IL-6 B

  • TNF

  • IF()

    T

  • CSF(6)


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THANK YOU


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