Peripheral tolerance and Immunoregulation. Dr. C. Piccirillo Canada Research Chair Department of Microbiology & Immunology McGill University MIMM-414A Lecture 1- Oct. 20, 2006 Why T cell regulation?
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Peripheral tolerance and Immunoregulation.
Dr. C. Piccirillo
Canada Research Chair
Department of Microbiology & Immunology
Lecture 1- Oct. 20, 2006
Why T cell regulation?
How does the immune system prevent self-reactivity while maintaining reactivity to invaders/non-self?
T cell regulation in the absence
of regulatory T cells?
A state of functional unresponsiveness for a particular antigen.
May occur in the context of a non-inflammatory immune response.
Tolerance is an active process.
cytokine production (eg; Th1-Th2).
Peripheral tolerance is an adaptable process.
Tolerance to Self Antigen
Immune Response to Foreign Antigens
Dose (low zone, high zone), timing/duration of exposure, routes, nature of antigen, protein > CHO >> lipids, presence of adjuvants
feedback inhibition (IgG inhibits IgM), differential antigen binding affinity
The reincarnation of the suppressor T cell
More questions than answers.
Number of publications
1995 - Present
A network of CD4+ regulatory T cells
control immune reponses.
Thymic CD4+ T cell pool
CD4+CD25+ Treg cells
CD4+ Treg cells
( iTreg )
Piccirillo et al. Trends in Immunol. 2004.