BRIM3 : tude de phase III vemurafenib versus dacarbazine- M thodologie
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BRIM3 : tude de phase III vemurafenib versus dacarbazine- M thodologie

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BRIM3 : tude de phase III vemurafenib versus dacarbazine- ...

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1. BRIM3 : ?tude de phase III vemurafenib versus dacarbazine- M?thodologie Etude de phase III multicentrique, randomis?e, comparant un inhibiteur de BRAF, le vemurafenib, ? la dacarbazine chez des patients porteurs d?un m?lanome et d?une mutation BRAFV600E Crit?res d?inclusion M?lanome non r?s?cable de stade IIIC ou IV Non ant?rieurement trait? Mutation BRAFV600E identifi?e (recherche centralis?e dans 5 laboratoires) : 47 % de patients avec pr?sence de la mutation ECOG PS: 0 ou 1 Absence de m?tastases c?r?brales


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