Proteinuria and nephrotic syndrome
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Proteinuria and Nephrotic syndrome. Case 1: Idiopathic Nephrotic Syndrome/ MCNS. CC/HPI: 8 Year old Female with Fever , sore throat x 4 days Puffiness around eyes and swelling of feet x 2 days Reduced urine output x 2 days

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Proteinuria and Nephrotic syndrome

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Proteinuria and nephrotic syndrome

Proteinuria and Nephrotic syndrome

Case 1 idiopathic nephrotic syndrome mcns

Case 1:Idiopathic Nephrotic Syndrome/ MCNS

  • CC/HPI: 8 Year old Female with

    • Fever , sore throat x 4 days

    • Puffiness around eyes and swelling of feet x 2 days

    • Reduced urine output x 2 days

  • H/o similar symptoms at 8 mths of age- diagnosed as Nephrotic Syndrome and treated with Prednisolone.

  • H/o multiple relapses – responding to steroids

  • Renal Biopsy at 5 yrs – Minimal Change Nephrotic Syndrome

  • 6 yrs – 6 weeks of cyclophosphamide therapy

  • Remained in remission till present symptoms onset

  • Examination laboratory

    Examination /Laboratory:

    • HR = 97 RR = 28 BP = 98/62

    • Temp = 100.8

    • Periorbital and pedal edema

    • HEENT : normal

    • No other significant findings

    • Na = 132 K = 4.2 Cl = 100 HCO3=23

    • BUN = 38 Creat = 0.7

    • Protein = 5.3(6-8)Albumin = 1.6 (3.6–5)

    • HB = 13 WBC = 18.6 Plt = 450

    • UA = Protein-500mg SG-1.015, Urine protein/creat = 14.4 (<0.1)

    • Cholesterol = 206

    • Blood Cultures = Negative

    Relapse of mcns post uri

    Relapse of MCNS post URI

    • Management during admission:

    • 1 dose of IV methylprednisolone

    • Followed by Prednisone PO 20 mg TID

    • Albumin 20% infusion ( furosemide cover)

    • Cephazolin 1 gm IV (till Cx negative)

    • Follow up :Remission + till last visit recently.

    Case 2 congenital nephrotic syndrome

    Case 2: Congenital Nephrotic Syndrome

    • CC/HPI: 21 month old female admitted for renal transplant

    • Born at 37 weeks, NVD.No abnormalities detected on prenatal US

    • 5 wks : repeated vomiting .US showed pyloric stenosis – Sx correction

    • B/L enlarged kidneys also noted on US

    • Workup – nephrotic range proteinuria and chronic renal failure

    • 6 wks – 9 mths : failure to thrive and 3 episodes of sepsis (CMV and H.influenza)

    • 12 mths : B/L pre-emptive nephrectomy followed by peritoneal dialysis, grow and development improved

    • 17 mths : viral myocarditis, transient CHF treated with digoxin

    • 21 mths : admitted for LRRT (father donor)

    Examination laboratory1


    • T = 98.3 HR = 112 RR = 24 BP = 114/75

    • Weight < 5%

    • Height < 5%

    • Abdomen : dialysis catheter in place.

    • Rest of exam : no significant findings

    • Na = 135 K = 5.6 Cl = 109 HCO3 = 19

    • BUN = 12 Creat = 0.8

    • WBC = 8.7 Hb = 16.3 Plt = 209

    • ECHO : normal cardiac function

    Further course

    Further Course

    • 21 mths : living related renal transplant with no major complications .

    • Discharge on immunosuppressant medication according to protocol

    • No rejections or serious infections

    • At last visit renal function was within normal limit

    • Growing well : Wt= 25-50% Ht= 10-25%

    • Normal developmental milestones for age

    Case 3 idiopathic multicenter osteolysis with nephropathy

    Case 3: Idiopathic Multicenter Osteolysis with nephropathy

    • CC/HPI:17 year old female who underwent renal transplant at the age of 11 years .

    • Presents with N&V for 5 days and acute deterioration of renal function

    • HPI: H/o carpal-tarsal bones osteolysis since early childhood.At 10 y/o : Persistent Proteinuria +(incidental finding – pt was asymptomatic). She was also found to have HTN

    • 2 mths later : Renal Biopsy – FSGS (steroid resistant nephrotic syndrome).She was put on Enalapril for HTN . Lost for follow up for 8 months.

    • 11y/o :pt had seizure (HTN encephalopathy). Found to have chronic renal failure with End Stage Renal Disease. Put on Peritoneal Dialysis and later Hemodialysis

    • One month later : Cadaveric Renal Transplant

    • 5 years post Transplant : Uneventful course with good renal function.She has been on Prednisone 15 mgQOD, Tacrolimus, Azathioprine

    Examination laboratory2


    • BP= 114/85 T=98.2 HR=108 RR=20

    • Wt >>95% Ht – 25-50%

    • Hirsuitism + Striae +

    • No signs of dehydration

    • Abdomen – normal bowel sounds

    • Rest of exam – no significant findings

    • Na=137 K=4.7 Cl=107 CO2=16 pH=7.28

    • BUN=69Creat=13.5 (baseline-1.0)

    • Ca = 7.0Phosphorus = 7.6

    • CBC : normal

    • Blood Cx : negative

    Further course1

    Further Course

    • Renal Biopsy : acute rejection

    • Treated with : IV methylprednisone followed by Prednisone PO 10mg QD

    • Renal Function gradually improved as shown by renal scan and Creat=6.0 on D/c

    • #3 weeks post D/C : Renal Function again deteriorated (creat=10.0).

    • Hemodialysis catheter placed in case urgent dialysis needed

    Proteinuria definition diagnosis

    Proteinuria: Definition/diagnosis

    • Normal renal function is associated with urinary protein excretion of ~150 mg/day or less. It is heterogenous is type and source, compromising plasma proteins, renal tissue enzymes and antigens and renal secretions.

    • Significant proteinuria can be defined:

      • Qualitative: 1+ on dipstick examination of 2 out of 3 random urine specimens collected one week apart if urine sp <= 1015 or 2+ in similarly collected urine if USG >1015

      • Semiquantitative: urine Pr/Cr ratio > 0.2 on early morning specimen ( r = 0.97 with 24 hs collection) in older children, >0.5 in infants. > 3 at any age is suspicious of nephrotic range.

      • Quantitative: Normal: <4 mg/m2/hour in 12-24 hs collection, Abnormal: 4-40 mg/m2/hour, Nephrotic range >40 mg/meter/hour

    Urinary protein excretion in healthy children

    Urinary protein excretion in healthy children

    Relationship of age to significant proteinuria

    ( based on weight at the 50th for median age for each age cathegory, values are given by 2 SD above the mean) ( Mitenyi et al, 1979)

    Proteinuria urine dispstick

    Proteinuria:Urine Dispstick

    • It is the easiest method, it typically reflects a range of concentrations: negative <15 mg/dl, trace 15-30 mg/dl, 1+ 30-100 mg/dl, 2+ 100-300 mg/dl, 3+ 300-1000 mg/dl, 4+ >1000 mg/dl

    • The reagent area is more sensitive to albumin than to globulins, hemoglobin, Bence-Jones protein and mucoprotein. A negative result does not r/o the presence of these other proteins.

    • False positives can occur in highly alkaline urine( pH>8), gross hematuria, pyuria, bacteriuria, quaternary ammoniun cleaners ( antiseptics)

    • False negatives can occur in very dilute urine or acidic urine ( pH 4.5) and non albumin proteinuria.

    Proteinuria screening

    Proteinuria: screening

    • Proteinuria is not uncommonly seen in patients, specially in the adolescent.

    • The AAP recommends an Urinalysis in middle childhood ( 5 y) and adolescence (preferred age 14 y). The sample should be a first morning void.

    • Gutgesell et al. studied the practicality of screening urinalysis in asymptomatic children in a primary care setting and found that the prevalence of initial asymptomatic proteinuria was asumed to be 6.3 % ( 89% FP)

    • Using 1+ proteinuria as significant on randomly collected urine ( non concentrated), the prevalence ranges between 5 to 6% and is is slightly higher in girls.

    Proteinuria screening1

    Proteinuria: screening

    • Most children who meet the criteria of proteinuria on initial testing lose their proteinuria over time after several subsequent urines are tested.

    • Due to high false positive/transient abnormality rate and low prevalence of disease, screening dipstick urinalysis can cause harm.

    • A definitive diagnosis or therapeutic decision should not be based on a single result or method.

    Proteinuria type and pathogenesis

    Proteinuria: Type and pathogenesis

    • 2 basic mechanisms :

    • Glomerular: increased filtered load or protein or altered glomerular permeability

    • Tubular: impaired tubular reabsorption of filtered protein

    • Mixed

    • 2/3 of the normally excreted protein in children is albumin, 1/3 is a combination of globulins and mucoprotein of tubular origin ( Tamm-Horsfall). The ratio is reversed in adults.

    Classification of proteinuria non pathological

    Classification of Proteinuria: Non-pathological

    • Postural ( orthostatic)

    • Febrile/histuria

    • Exercise-induced

    Classification of proteinuria pathological


    Inherited: cystinosis, Wilson disease, Lowe syndrome

    Acquired: antibiotic-induced, interstitial nephritis, ATN, heavy metal poisoning ( lead, mercury, gold), reflux nephropathy


    Nephrotic syndrome: MCNS, mesangial proliferation, FSGS, CNG/Infantile

    Glomerulonephritis: Idiopathic( membranous, membranoproliferative), Systemic diseases ( SLE)




    Hyperfiltration secondary to nephron loss ( with or without FS) due to chronic pyelonephritis or other renal diseases

    Classification of Proteinuria:Pathological

    Tubular vs glomerular proteinuria

    Tubular vs glomerular proteinuria

    Work up of a child with proteinuria

    Pediatrician’s work up:

    early morning urinalysis to include examination of sediment

    Ambulatory and recumbent urinalysis for Dipstick protein

    Blood electrolytes, BUN, Cr, serum proteins, cholesterol

    ASO titer, C3 complement, ANA, hepatitis B serology

    Timed 12-hour urine collections, recumbent and ambulatory

    Renal US, VCUG, renal scan

    When to refer:

    Persistent nonorthostatic proteinuria

    Family history of GN, CRF, kidney transplantation

    Systemic complaints ( such as fever, arthritis and skin)

    HTN, edema, cutaneous vasculitis, purpura

    Coexistent hematuria with or without casts

    Elevated BUN/Cr

    Increased parental anxiety

    Work-up of a child with proteinuria

    When to consider renal biopsy

    When to consider renal biopsy

    • Proteinuria <1 gm/day and hematuria, decreased Cr clearance, persistent decreased C3, HTN

    • Proteinuria in nephrotic range ( <1 or >8 years)

    • Unexplained FTT and proteinuria

    • Diminished renal function with low grade proteinuria

    • Family’s need to know a specific diagnosis

    Nephrotic syndrome

    Nephrotic syndrome

    • The term nephrotic syndrome is applicable to any condition with heavy proteinuria, hypoproteinemia, and edema.

    • It is a disorder of glomerular permselectivity that may be primary or secondary to an overt systemic disease.

    • In children the most common variety is MCNS with a characteristic response to corticosteroid therapy

    • But a few patients with MCNS do not respond to steroids , and a few steroid responders have histology other than MCNS.

    Nephrotic syndrome definitions

    Nephrotic syndrome: Definitions

    Nephrotic syndrome: edema, plasma albumin less 2.5 gm/dl, proteinuria >40 mg/m2/h

    Remission: urinary protein excretion < 4 mg/m2/h or dipstick neg/trace for 3 consecutive days

    Steroid response: remission achieved with steroid therapy alone

    Late responder: remission occurring after 4 weeks prednisolone 60 mg/m2/day without other drugs

    Relapse: urinary protein excresion >40 mg/m2/h or dispstick 2+ for 3 consecutive days having previously been in remission

    Frequent relapses: two or more relapses within 6 months of initial response or 4 or more in 12 months

    Steroid dependence: two consecutived relapses occurring during corticosteroid treatment or within 14 days of cessation

    Steroid resistance: failure to achieve response in spite 8 weeks of prednisolone 60 mg/m2/day

    Early nonresponder: steroid resistance in the initial episode

    Late nonresponder: steroid resistance developing in a patient who had previously been steroid responsive

    Idiopathic nephrotic syndrome

    Idiopathic nephrotic syndrome

    Children with steroid-resistant NS may have one of several different histologic appearances in the glomeruli, being most common FSGS.

    It is not clear is MCNS and FSGS should be consider two different entities or different ends of a single spectrum of disease.

    Current opinion is to include both conditions under the single label of Idiopathic Nephrotic Syndrome, dividing into steroid-sensitive (SSNS) and steroid-resistant (SRNS). Patients with SRNS have higher risk for extrarenal complications as well as porgression to CRF and ESRD, with high recurrence in the graft after transplantation.

    Ins epidemiology

    INS: Epidemiology

    • Prevalence is ~16/100000 children, annual incidence of 2-7/100000 children

    • Ratio M/F is 2/1, in younger children. This male predilection disappears in teenagers and adults

    • 3/4 less than 6 years

    • Median ages at time of presentation varies according to histopathological diagnosis: 3 years for MCNS, 6 years for FSGS and 10 years for MPGN

    • Majority of patients that have SSNS has MCNS. The risk of progressing to CRF and ESRD for SRNS is 40% in 5 years.

    Ins treatment

    INS: treatment

    • Immunosuppressants: corticosteroids, alkylating agents ( or combination), CSA, Mycophenolate Mofetil, azathioprine

    • Plasmaferesis

    • ACE inhibitors

    • Treatment of complications: edema, HTN, infections, thromboembolic events, hyperlipidemia, malnutrition, anemia, endocrine abnormalities

    Inheritable forms of srns

    Inheritable forms of SRNS

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