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Neurotransmitter Release

Neurotransmitter Release. High voltage . Low voltage. Mechanism of Exocytosis synapsin s anchor vesicle to cytoskeleton  Ca 2+ influx activates Ca 2+ /calmodulin dependent kinase (CaMK) phosporylaton of synapsin I release of vesicle from cytoskeleton move to active zone

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Neurotransmitter Release

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  1. Neurotransmitter Release

  2. High voltage Low voltage

  3. Mechanism of Exocytosis synapsins anchor vesicle to cytoskeleton Ca2+ influx activates Ca2+/calmodulin dependent kinase (CaMK) phosporylaton of synapsin I release of vesicle from cytoskeleton move to active zone Rab3A binds to vesicle hydrolysis of Rab GTP to GDP + PO4 targeted to docking site at active zone interaction of v-SNARES and t-SNARES docking and membrane fusion exocytosis and release of Rab into cytoplasm t-snares = syntaxin and SNAP25 v-snare = synaptobrevin (VAMP)

  4. http://www.youtube.com/watch?v=eRslV6lrVxY

  5. http://www.youtube.com/watch?v=K7yku3sa4Y8

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