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Wildtype versus Mutant. Ms. Alvarez [email protected] Arora Lab University of California Irvine Developmental and Cell Biology Department. UC Irvine. Dr. Kavita Arora Associate Professor. J. Cho PhD Student. M. Alvarez PhD Student.

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Wildtype versus mutant

Wildtype versus Mutant

Ms. Alvarez

[email protected]

Arora Lab

University of California Irvine

Developmental and Cell Biology

Department


Uc irvine
UC Irvine

Dr. Kavita Arora

Associate Professor

J. Cho

PhD Student

M. Alvarez

PhD Student


What is the difference between these individuals
What is the difference between these individuals?

  • Wolverine is a mutant and Ms. Alvarez is wild-type

  • Wild-type is the typical form

  • Mutants are organisms who’s DNA has been altered. These organisms display new characteristics or traits not found in wild-type.



Why do scientist make mutant organisms
Why do scientist make mutant organisms? gene

  • The image “http://nfs.unipv.it/nfs/minf/dispense/immunology/nunu_mouse2.jpg” cannot be displayed, because it contains errors.

  • To study the function/ role of the gene that has been mutated.


Drosophila melanogaster a popular genetic model organism
Drosophila Melanogaster, a popular genetic model organism gene

  • ~ 50% of fly genes have vertebrate homologs

  • Small and easy to grow in lab

  • Short generation time

  • Produce high amounts of offspring


Drosophila melanogaster is used to study the biological processes underlying
Drosophila Melanogaster is used to study the biological processes underlying:

  • Embryonic development

  • Neurodegenerative disorders

  • Diabetes

  • Aging

  • Drug abuse

  • Cancer


Myostatin Mutants processes underlying:


Project goal identify the function of myostatin in drosophila
Project goal: Identify the function of Myostatin in Drosophila

Myostatin fly mutants die at pupa stage


Acknowledgments Drosophila

Dr. Kavita Arora

Jane Cho

Tiffany Leung

Nicole El-Ali

Arora Lab

Warrior Lab

MSP Program

NSF-GK-12 grant DGE-0638751


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