Wildtype versus mutant
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Wildtype versus Mutant. Ms. Alvarez maribea@uci.edu Arora Lab University of California Irvine Developmental and Cell Biology Department. UC Irvine. Dr. Kavita Arora Associate Professor. J. Cho PhD Student. M. Alvarez PhD Student.

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Wildtype versus Mutant

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Wildtype versus Mutant

Ms. Alvarez


Arora Lab

University of California Irvine

Developmental and Cell Biology


UC Irvine

Dr. Kavita Arora

Associate Professor

J. Cho

PhD Student

M. Alvarez

PhD Student

What is the difference between these individuals?

  • Wolverine is a mutant and Ms. Alvarez is wild-type

  • Wild-type is the typical form

  • Mutants are organisms who’s DNA has been altered. These organisms display new characteristics or traits not found in wild-type.

Mutations are permanent changes in the DNA sequence of a gene

Why do scientist make mutant organisms?

  • The image “http://nfs.unipv.it/nfs/minf/dispense/immunology/nunu_mouse2.jpg” cannot be displayed, because it contains errors.

  • To study the function/ role of the gene that has been mutated.

Drosophila Melanogaster, a popular genetic model organism

  • ~ 50% of fly genes have vertebrate homologs

  • Small and easy to grow in lab

  • Short generation time

  • Produce high amounts of offspring

Drosophila Melanogaster is used to study the biological processes underlying:

  • Embryonic development

  • Neurodegenerative disorders

  • Diabetes

  • Aging

  • Drug abuse

  • Cancer

Myostatin Mutants

Project goal: Identify the function of Myostatin in Drosophila

Myostatin fly mutants die at pupa stage


Dr. Kavita Arora

Jane Cho

Tiffany Leung

Nicole El-Ali

Arora Lab

Warrior Lab

MSP Program

NSF-GK-12 grant DGE-0638751

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