Research Networks Working together to help Deliver Research

1. Research NetworksWorking together to help Deliver Research Chaired by Ruth Allen, Network Manager, Medicines for Children Research Network (SW) Jacqueline Briggs, Network Manager, Peninsula Stroke Research Network Rachel Exell, Network Manager, Primary Care Research Network (SW) Helen Jones, Senior Manager, Western Comprehensive Local Research Network Helen Quinn, Senior Manager, Peninsula Comprehensive Local Research Network On behalf of Research Networks across the South West

2. Find out how the networks can practically support Chief Investigators of single and multi-centre research studies Find out how the networks can support Principal Investigators and Research Teams Find out how the networks work together to help deliver research Find out more about the different funding available to Trusts to support both clinical and support services Research Networks

3. Research Networks • The National Institute Health Research (NIHR) Clinical Research Network (CRN) is working to develop and strengthen NHS infrastructure to support the delivery of clinical research 

5. Research Networks • Clinical Research Networks- coordinate and support research in: • Cancer (CRN) • Dementias and Neurodegenerative Diseases (DeNDRoN) • Diabetes (DRN) • Medicines for Children (MCRN) • Mental Health (MHRN) • Primary Care (PCRN) • Stroke (SRN)

6. Research Networks • A Comprehensive Clinical Research Network supports research in all areas of disease and clinical need. • 25 Comprehensive Local Research Networks (CLRNs) across England, including 2 South West CLRNs: • PenCLRN • Western CLRN

7. Research Networks in the South West • South West Medicines for Children Research Network • South West Peninsula Diabetes Research Network • South West Primary Care Research Network • Three Counties Cancer Research Network • Thames Valley Cancer Research Network • Western Comprehensive Local Research Network • West Mental Health Research Network Hub • Avon, Somerset and Wiltshire Cancer Research Network • Central South Coast Cancer Research Network • Dorset Cancer Research Network • Peninsula Cancer Research Network • Peninsula Comprehensive Local Research Network • Peninsula Stroke Research Network • South Coast Dementias and Neurodegenerative Diseases Research Network • South West Dementias and Neurodegenerative Diseases Research Network

8. How the networks can practically support Chief Investigators of single and multi-centre research studies

9. Chief Investigators and their teams Access to a whole network of sites and information Detailed Feasibility including: Patients available e.g. past experience / over researched Capacity of sites Facilities Strategic site identification and recruitment strategy Promotion of the study Clinical / non-clinical advice on practicalities of the protocol design Support to ‘set up’ study across a number of sites Support to ensure sites are able to undertake the study e.g. generic training / staff development Assist with performance management / ongoing issues

10. Chief Investigators and their teams Example: Increase in community hospital based research where there was no previous activity (SRN/PCRN & CLRN) Chief Investigator: Professor Ann Forster A cluster randomised controlled trial of a structured training programme for caregivers of in-patients after stroke South West Sites Mount Gould PI Claire Gatehouse/Ben Hyams Crediton / Budleigh PI Tim Ayers/Leigh Barron Newton Abbot PI Rhoda Allison/Nicola Wedge Camborne & Redruth PI Stephanie Coltman /Cory Wroath Taunton / Williton PI Susan Glanfield/Libby Caudwell Weston Super Mare links with PSRN as part of the South West cluster

11. The ESTEEM trial: Triage Systems for Same Day Appointments in General Practice (£2.5m) multi-centre trial (Intensive intervention in each practice Triage - Nurse, GP or usual care) PCRN Director advised on protocol Approved for funding by HTA Linking early with CI in order to facilitate adoption process and agree recruitment strategy Advice on Service Support Costs and Excess Treatment Costs Close links with the three academic Departments of Primary Care Chief Investigators and their teams

12. How the networks can support Principal Investigators and Research Teams

13. Principal Investigators and Research Teams • Support staff in all aspects of research to aid recruitment • Study feasibility & review • Ensure Service Support Costs & RM&G approvals obtained • Assist with recruitment strategy • Level of staff support agreed • Promotion of studies through Primary Care Incentive Scheme • access to over 1,000 general practices, 20-25% have agreed to do NIHR PCRN studies • Information about forthcoming studies (email alert to site/practices) • Training and education in generic research activities (GCP) • Sharing of solutions and ideas relating to the study across sites/practices

14. Research Teams Training and education Links with other networks Sharing good practice Formal & Informal support as part of a network e.g. team meetings / teleconferences and one-to-one calls Staff development and retention Advice on future studies and development options

15. Whole System Demonstrator Programme (WSD) (PCRN & CLRN) Cluster randomised trial (telemedicine – chronic disease) Protocol reviewed by PCRN Meeting research team early to agree level of support Recruitment in an under researched geographical area Research Officer provided to identify patients & facilitate recruitment – (PCRN/PenCLRN) Rates of Psychiatric Illness in Long-term Survivors of Early Childhood Brain Tumours (Psych-BTS) (PCRN & MHRN) Rare condition Recruitment strategy agreed across South West (PCRN/MHRN) Teleconference involving all Networks Plan formulated to ensure Research Officers cover across 13 PCTs Training requirements agreed

16. Principal Investigators and Research Teams Example: Increase in Topic Network Research In North Devon CLRN/DRN/SRN Working with the comprehensive network to set up a new joint research nurse post in North Devon. This has enabled the increase of the diabetes and Stroke research portfolio and new links with the consultants and clinical teams In general the networks have supported new investigators in both primary and secondary care to begin to build a local portfolio and integrate research into their clinical service thus increasing NHS infrastructure

17. How the networks work together to help deliver research

18. South West (SW) Network Managers Group • Representation from CLRNs, PCRN (SW), TCRNs which have a presence in the SW • Meets quarterly • Discuss key work areas which networks have a remit for to ensure integrated SW approach including: • Training and Education • Patient and Public Involvement • Industry

19. Streamlining funding application processes • Streamlined system for applying for FSF funding to ensure no duplication • SW application forms and guidance

20. Working together in primary care • Primary Care Research Network (PCRN) South West (SW) • Covers 3 CLRNs (including PenCLRN and Western CLRN) • Joint CLRN/ PCRN Research Officers/ Clinical Lead posts • Joint CLRN/ PCRN Clinical Study Officer post • Endorsement of the SW PCRN costing template • Involvement in the Primary Care Incentive Scheme (PCIS) • Co-ordinated approach to funding sessional support in primary care

21. Shared resources to meet researchers’ needs • CLRN funded and joint funded research posts in MHRN, CRN, PCRN, SRN • Including: • Clinical Studies Officers • Research Nurses • Research Administrative Assistants • Pharmacy Practitioners

22. Study Example (1): Working together to help deliver research • COCOA:Care of Offenders: Continuity of Access- UKCRN ID 5131 • UK Multi-centre observational study funded by NIHR Service Delivery and Organisation Program • NIHR Portfolio Study- co-adopted by PCRN • Chief Investigator based in Plymouth with research sites across PenCLRN and Western CLRN • Research team struggling to recruit into study so approached Pen CLRN for support • Teleconference with mental health trust in the area, PenCLRN SW MHRN and PCRN • Arranged for Clinical Studies Officers to help recruitment in all sites including Plymouth, Exeter and Bristol

23. Study Example (2): Working together to help deliver research • MASCOT: Management of Asthma in School-age Children On Therapy: UKCRN ID 3774 • UK Multi-centre interventional study funded by HTA • NIHR portfolio study- adopted by MCRN and co-adopted by PCRN and respiratory • Chief Investigator based in University Hospital of North Staffordshire • WCLRN and PenCLRN involvement via PCRN (SW) • PCRN (SW) staff are training Practice staff to take part in the study, supporting Practice database searches and are preparing recruitment material to be sent by Practices

24. Different funding available to Trusts to support both clinical and support services

25. Funding • Flexibility and Sustainability Funding • Sessions • Training and Education • PPI • Key Service Support • General Service Support • Primary Care Incentive Scheme • Research Management and Governance

26. Flexibility and Sustainability Funding ‘FSF’ • Trust • Network • Joint Application System Peninsula - andrena.lynes@phnt.swest.nhs.uk Western - hope.douglas@uhbristol.nhs.uk

27. Sessions • Sessions for clinicians of all professions • Administrative support • Consultation – Networks Trusts Research Teams

28. Training and Education • Non-pay costs attached to sessions • Ring fenced funding held centrally • NIHR courses

29. Key Service Support • Unblocking the blocks • First ‘call’ pharmacy and Imaging • Initially 2008-2010 • PenCLRN Example • Western CLRN Example

30. General Service Support • All support services • Accurate ‘costings’ • Non-commercial costings template • Managed bureaucracy

31. Primary Care Incentive Scheme‘PCIS’ • In conjunction with PCRN • Level one and two • Performance managed

32. Research Management & Governance • Funding for Managers and Admin • Both networks devolved models

33. Summary • SW networks aim to increase the number of studies available on the Portfolio and maximise on recruitment • SW networks are committed to ensure any potential ‘blocks’ to research are resolved • CLRNs, PCRN & TCRNs are committed to providing the necessary support to ensure the SW is fully supported to participate in NIHR portfolio studies

34. Contact Details • Chaired by Ruth Allen, Network Manager, Medicines for Children Research Network (SW): Ruth.Allen@bristol.ac.uk • Jacqueline Briggs, Network Manager, Peninsula Stroke Research Network: Jacqueline.Briggs@rdeft.nhs.uk • Rachel Exell, Network Manager, Primary Care Research Network (SW): rachel.exell@pms.ac.uk • Helen Jones, Senior Manager, Western Comprehensive Local Research Network: HelenZ.Jones@uhbristol.nhs.uk • Helen Quinn, Senior Manager, Peninsula Comprehensive Local Research Network: Helen.Quinn@phnt.swest.nhs.uk

35. Questions?