Ctrl

1. Supplementary Figure S1 Ctrl AOPP AOPP+α-RAGE 2.5 μg/ml AOPP+α-RAGE 5 μg/ml AOPP+α-RAGE 10 μg/ml AOPP+α-RAGE 20 μg/ml

2. Supplementary Figure S2 Ctrl AOPP AOPP+α-SR-BI AOPP+α-CD36 AOPP+α-SR-A AOPP+α-TLR4 AOPP+α-LOX1 AOPP+α-AGE-R3

3. Supplementary Figure S3 Ctrl AOPP AOPP+siRAGE AOPP+NC-siRNA

4. Supplementary Figure S4 A B Intracellular ROS production Intracellular ROS production0 medium alone 4 4 medium alone AOPP AOPP * * * * # # 2 # 2 # # # 0 0 +MSA +MSA +nonimmuno IgG +a-RAGE 5ug/ml +nonimmuno IgG +a-RAGE10ug/ml +a-RAGE 20ug/ml +a-RAGE 20ug/ml +a-RAGE(B22) 80ug/ml +a-RAGE(B22) 20ug/ml +a-RAGE(B22) 40ug/ml +a-RAGE(B22) 80ug/ml +a-RAGE(B22) 80ug/ml C D Intracellular ROS production Intracellular ROS production 4 medium alone medium alone 4 AOPP AOPP * * * * # # # 2 2 # # # # 0 0 +MSA +MSA +a-RAGE 5ug/ml +nonimmuno IgG +nonimmuno IgG +a-RAGE10ug/ml +a-RAGE 20ug/ml +a-RAGE 20ug/ml +a-RAGE(B22) 80ug/ml +a-RAGE(B22) 20ug/ml +a-RAGE(B22) 40ug/ml +a-RAGE(B22) 80ug/ml +a-RAGE(B22) 80ug/ml