ALLHAT. Implications of ASCOT Results for ALLHAT Conclusions. ALLHAT. Overall Implications. ASCOT was not a comparison of initial treatment with newer drugs versus thiazide diuretic-based treatment—therefore, no change in ALLHAT conclusions.
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Dahlof B, Sever PS, Poulter NR, et al.; ASCOT Investigators. Lancet. 2005;366:895-906.
1 Dahlof B, Devereux RB, Kjeldsen SE et al. Lancet 2002;359:995-1003.
2 MRC Working Party. Br Med J 1992;394:405-412.
"Our present results might affect the interpretation of two of the latest large hypertension trials--the LIFE and the ASCOT-BPLA trial--both of which claim the superiority of newer antihypertensive drugs. Our analyses suggest an alternative interpretation is that the beta blocker in these two mega-trials had a less than optimum cardiovascular effect.“
Lindholm et al., www.thelancet.com, published online October 18, 2005
BFMZ = bendroflumethiazide; HCTZ = hydrochlorothiazide