Kristian Andvord’s break-through observation. Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60. The “Koch Phenomenon”. A primary infection leads to a delayed response and has often a mild and self-limited course
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Kristian Andvord’s break-through observation
Andvord K F. Norsk Magasin for Lægevidenskapen 1930;91:642-60
The “Koch Phenomenon”
A primary infection leads to a delayed response and has often a mild and
A reinfection results commonly in a rapid response with tissue necrosis
Drawings: Koch R. Mittheilungen aus dem Kaiserlichen Gesundheitsamte 1884;2:1-88.
Phenomenon: Koch R. Dtsch Med Wochenschr 1891;17:101-2.
Morbidity / mortality
Remaining live bacilli
Time / age
BMRC BCG Trial
Effect of Environmental Mycobacteria:
Blocking and Masking Hypothesis
Andersen P, et al. Nature Rev 2005;3:656-62
…and another research question:
If an individual is not protected by BCG, is
tuberculosis more severe in this individual?
Operating Characteristics of IGRAs
Pai M, et al. Expert Rev Mal Diagn 2006;6:413-22
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