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Listeria Cycle of Propagation

Listeria Cycle of Propagation. Cell migration: a cyclic process of force generation. Membrane-Cyto. Adhesion Resists Extension a PIP2. Sheetz, Nature Rev. MCB. 2:392 (2001). Extracellular Matrix Adhesion Linked to Force Generation by Rearward Flow.

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Listeria Cycle of Propagation

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  1. Listeria Cycle of Propagation

  2. Cell migration: a cyclic process of force generation Membrane-Cyto. Adhesion Resists Extension a PIP2. Sheetz, Nature Rev. MCB. 2:392 (2001) Extracellular Matrix Adhesion Linked to Force Generation by Rearward Flow How do cells locally trans-duce Matrix rigidity into a signal used to direct cell edge extension?

  3. Lamellipodial extension driven by actin assembly Rac-GTPase lamellipodia lamella Actin plolymerization (front) and depolymarization(rear) define the lamellipodial width Forces generated by Myosins? Cell spreading and migration require myosin activity

  4. Model for Propulsion of Listeria

  5. Several Pathogens Co-Opt Actin

  6. Salmonella Injects Critical Proteins

  7. Shigella Targets MTs and Actin

  8. Mycobacteria Modify Actin Dynamics

  9. Enteropathic E. coli Break Contacts

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