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Lab 9: Endocrine System. Review. Where does pepsinogen come from? Why doesn’t the stomach digest itself? Why can Veggans not eat meat anymore?. Function. Maintain Homeostasis (Balance) Communicates and coordinates physiological responses Example of Imbalance?. DVD clip Battling A Giant.

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Lab 9: Endocrine System

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Lab 9 endocrine system

Lab 9: Endocrine System



  • Where does pepsinogen come from?

  • Why doesn’t the stomach digest itself?

  • Why can Veggans not eat meat anymore?



  • Maintain Homeostasis (Balance)

    • Communicates and coordinates physiological responses

  • Example of Imbalance?

Dvd clip battling a giant

DVD clipBattling A Giant



  • Chemical messengers

    • Stimulate physiological responses in other cells

    • Target Cells

  • Tropic (Trophic) Hormones

    • Hormone whose target is another endocrine gland.

  • How do hormones travel?

Hormone production and distribution

Hormone Production and Distribution

  • Production

    • Endocrine Glands

    • Gland: an organ specialized to produce secretions

  • Distribution

    • Relies on blood circulatory system

  • How does this compare to nervous system?

Endocrine glands








Endocrine Glands



  • Location- Base of brain case

  • Functions- Regulation of Primitive or Basal activities such as sex drive and water balance

  • 9 hormones-

    • 7 act on anterior lobe of pituitary gland (Tropic)

    • 2 stored in posterior lobe

Hypothalamo hypophyseal portal system

Hypothalamo-hypophyseal portal system

  • What type of vessels comprise a portal system?

  • What is unique about a portal system?

Hypothalamo hypophyseal portal system and tract

Hypothalamo-hypophyseal portal system and tract

  • Location-

    • Pituitary Stalk (Infundibulum)

  • Link the hypothalmus to the pituitary gland

  • Portal- Capillary beds connect to anterior lobe

  • Tract- Neurons connect to posterior lobe

Pituitary gland

Pituitary gland

  • Location- Sphenoid bone of the skull

  • Anterior Lobe

    • Produces Six hormones that Regulate

      • Reproduction

      • Growth

      • Activity of the Thyroid Gland

  • Posterior Lobe

    • No hormone production only storage of hypothalamic hormones



  • Largest endocrine gland

  • Location- Wrapped around anterior and lateral sides of Trachea, just below Larynx

  • Hormone- Thyroid Hormone

  • Function- Increases Metabolic Rate

Parathroid glands

Parathroid Glands

  • Location- Four glands imbedded on posterior surface of Thyroid

  • Hormone- Parathyroid Hormone

  • Function- Calcium Regulation

Adrenal glands


Zona Glomerulosa: Outer layer

Zona Fasciculata: Middle Layer

Zona Reticularis- Inner Layer


Location- 2 glands one superior to each Kidney.

Adrenal Glands

Adrenal glands1


Zona Glomerulosa

Mineralocorticoids- Regulate Kidney Na+ and K+ excretion

Zona Fasiculata

Glucocorticoids- Stress and immune supression

Zona Reticulata-

Sex steroids- androgens precursor to sex hormones

Medulla- (Fight or Flight Response) Epinepherine and Norepinephrine

Adrenal Glands


Location- Inferior and posterior to Stomach

Pancreatic Islets

Clusters of endocrine cells

Function- Glucose Regulation




  • Male- Testes

    • Secrete Androgens such as Testosterone

  • Female- Ovary

    • Secrete Estrogen and Progesterone

Dnh anatomy

DNH- Anatomy

Homeostatic control

Homeostatic Control

  • Metabolic Rate

  • Growth Hormone

  • Blood Glucose Levels

  • Blood Calcium Levels

  • Water Retention

  • Stress

Metabolic rate

Metabolic Rate

Interactions between metabolic hormones

Interactions between Metabolic Hormones

T4 & T3

Metabolic rate1

Metabolic Rate

  • Hormones released in response to a decrease in T3 blood levels

  • Affects: All cells in the body except brain, spleen, testes, uterus and the thyroid gland

  • Results: Increase in basal metabolic rate, oxygen consumption and heat production


Hypothyroidism (Creatinism)

Children: mental retardation, development abnormalities

Adults: lethargy, obesity


Hyperthyroidism (Graves’ Disease)

Weight loss, sweating, nervousness, sleeplessness


-----a hypertrophy of the thyroid gland resulting from iodine deficiency




  • Gland- Pituitary Gland

  • Hormone-

    • Growth Hormone: increases mitosis and cellular differentiation.

    • Secreted in response to Sleep, Trauma, Exercise, High protein meals, and Low blood sugar

  • Effects

    • Directly: Liver

    • Indirectly: Bone, Muscle, and Cartilage


Pituitary Dwarfism- Insufficient secretion of Growth Hormone

Gigantism- Over-secretion of Growth Hormone


Blood glucose levels

Blood Glucose Levels

  • Gland- Pancreas

  • Hormones

    • Insulin- increases uptake of glucose by cells

    • Glucagon- increases release of glucose by cells and increases liver glucose production

  • Released in response to…

    • Insulin: high blood glucose levels

    • Glucagon: low blood glucose levels

  • Effects-

    • Systemic

    • Liver



  • Diabetes Mellitus- Disruption of Metabolism due to lack of insulin or lack of response to insulin.

  • Symptoms- Excessive Urine, Intense Thirst, and Ravenous Hunger

  • Type I- (Juvenile of Insulin Dependant) Destruction of Insulin Producing Cells

  • Type II- (Adult or Noninsulin Dependant) Target cells resistant to Insulin

Blood calcium levels

Blood Calcium Levels

  • Gland- Parathyroid

  • Hormone- Parathyroid hormone

    • Released in response to low calcium levels

  • Effects

    • Kidneys- Retain Calcium

    • Bones- Release Calcium



  • Hyper- or Hypo-parathyroidism

    • Hyper-parathyroidism: Over Secretion

      • Soft, Fragile Bones

      • Kidney stones

    • Hypo-parathyroidism: Under Secretion

      • Rapid Decline of Blood Calcium

      • Fatal

Water retention

Water Retention

  • Gland- Hypothalamus

    • Stored and released by posterior pituitary

  • Hormone- ADH

    • Released in response to Dehydration and High Osmolarity (thickening) of blood

  • Effects?





  • Gland- Adrenal Cortex

  • Hormones

    • Glucocorticoids

  • Effect- Systemic



  • Cushing Syndrome

    • Cause: Excess Glucocorticoids

    • Disrupts Protein and Fat Metabolism

    • Symptom is abnormal fat deposits, fatigue and exhaustion

Cushing syndrome cont

Cushing Syndrome (cont.)

After Surgery

Dissection review

Dissection & Review

  • Cat Questions-

    • You won’t need to find the specific glands

    • You will need to know region of the body where found

    • You will need to know location of organs affected

  • Lab Notes at Library on Reserve

  • Research Papers Next Week Due

  • Reviews for final exam will be in Two Weeks.

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