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菌心说 --- 一场静悄悄的革命. 思想要创新 科研要创新 医疗要创新 知识要创新. 北美医学教育基金会. 创新是一个民族进步的灵魂,是一个国家兴旺发达的不竭动力. 张成岗提出菌心说. 【 菌心说 】 意味着人类对于自己、社会以及自然的认识前进了一大步. 军事医学科学院放射与辐射医学研究所电磁与激光生物学研究室主任,研究员,博士生导师,蛋白质组学国家重点实验室副主任。. 目录. 我对菌心说的理解 肠道菌群与健康和疾病概述 肠 - 脑轴 肠 - 肝轴 肠道菌群与代谢性疾病:肥胖、糖尿病 肠道菌群与肠病 肠道菌群与免疫 肠道菌群与其它疾病

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菌心说 --- 一场静悄悄的革命

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菌心说---一场静悄悄的革命

思想要创新

科研要创新

医疗要创新

知识要创新

北美医学教育基金会

创新是一个民族进步的灵魂,是一个国家兴旺发达的不竭动力


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张成岗提出菌心说

【菌心说】意味着人类对于自己、社会以及自然的认识前进了一大步

军事医学科学院放射与辐射医学研究所电磁与激光生物学研究室主任,研究员,博士生导师,蛋白质组学国家重点实验室副主任。


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目录

  • 我对菌心说的理解

  • 肠道菌群与健康和疾病概述

  • 肠-脑轴

  • 肠-肝轴

  • 肠道菌群与代谢性疾病:肥胖、糖尿病

  • 肠道菌群与肠病

  • 肠道菌群与免疫

  • 肠道菌群与其它疾病

  • 革命带来的挑战和机遇

菌心说是一个概括


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我对菌心说的理解

  • 肠道菌群是人体健康和疾病的核心。

  • 肠道菌群是人生存的一个中心器官。

  • 肠道菌群和“心”的关系:

    • 脑肠轴的概念

    • 肠道菌群和心血管疾病


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主要创始人

  • 学历:

    • Tufts大学博士后

    • Boston大学博士

    • 美国国际教育中心医学博士认证

    • 北京体育大学运动医学硕士

    • 首都医科大学学士

  • 工作经历

    • 美国USDA HNRCA副研究员

    • Boston 大学教授助理

    • Quincy 学院讲师

    • 哈佛大学研究助理

美国广州、沈阳总领事商务副领事感谢北美医学基金会和北美医学教育基金会对中美医学交流的支持和贡献,专程到我们的展位表示谢意。

  • 北美医学教育基金会主要创始人


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Jeremy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.


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  • Through the ongoing National Institutes of Health Roadmap ‘Human Microbiome Project’ and similar projects in other parts of the world, a large coordinated effort is currently underway to study how microbiota can impact human health. Translating findings from these studies into effective interventions that can improve health, possibly personalized based on an individuals existing microbiota, will be the task for the next decade(s).


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悄悄发生的革命

INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;


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一篇值得关注的综述

Nature reviews. Microbiology 最新的影响因子为22.490 (2013)


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人菌共生

Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.


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人肠道菌群种类和数量

EAMONN M. M. QUIGLEY and RODRIGO QUERA, Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics. GASTROENTEROLOGY 2006;130:S78–S90


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好细菌和坏细菌


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菌群是健康的核心

Nathalie M. Delzenne, et al., Targeting gut microbiota in obesity: effects of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639–646 (2011).


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肠道菌群对人生理的影响


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肠道菌群-代谢产物-功能

Jeremy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.


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影响肠道菌群的因素

Nathalie M. Delzenne & Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31.


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影响肠道菌群的因素


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肠道菌群紊乱引发的疾病


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肠-脑轴/脑-肠轴


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  • Germ Free (GF) Mice Display Increased Motor Activity and Reduced Anxiety-Like Behavior.

  • results suggest that the microbial colonization process initiates signaling mechanisms that affect neuronal circuits involved in motor control and anxiety behavior.


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肠-脑轴的概念

Augusto J. Montiel-Castro, et al., The microbiota–gut–rainaxis: neurobehavioral correlates, healthand sociality. Front in Integ Neuro. Oct 2013 | Vol7 | Article 70 | 1-16.


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脑-肠轴/肠-脑轴:迷走神经

Sue Grenham,et al., Brain–gut–microbe communication in health and disease. Frontiers in Physio. Gastroint Sci Dec 2011 Vol 2 p 1-15.


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肠脑轴/脑肠轴

Q. AZIZ, et al., Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterol Motil (2013) 25, 4–15.


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菌群影响神经功能

Eamonn M.M. Quigley. Do patients with functional gastrointestinal disorders have an altered gut flora? Ther Adv Gastroenterol (2009) 2(Suppl 1) S23–S30.


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菌群紊乱致焦虑和抑郁

Jane A. Foster and Karen-Anne McVey Neufeld, Gut–brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences, May 2013, Vol. 36, No. 5, P 305-312


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精神活动影响肠道菌群

exposure to psychological stress results in a significant reduction in the production of mucin and a decreased presence of acidic mucopolysaccharides on the mucosal surface.

Jason A. Hawrelak & Stephen P. Myers, The Causes of Intestinal Dysbiosis: A Review. Altern Med Rev 2004;9(2):180-197.


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应激/压力引起胃肠疾病

P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.


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脑肠轴紊乱导致溃疡

P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.


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应激导致IBD

P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.


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应激导致IBS

P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.


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慢性疲劳与肠-脑轴


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肠道菌群和自闭症

  • GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD.

  • Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors.

  • autism, and likely other behavioral conditions, are potentially diseases involving the gut that ultimately impact the immune, metabolic, and nervous systems, and that microbiome-mediated therapies may be a safe and effective treatment for these neurodevelopmental disorders.

  • these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders.

Elaine Y. Hsiao, et al., Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders. Cell 155, 1451–1463,


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肠-脑轴和自闭症

Caroline G.M. de Theije, et al., Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management. European Journal of Pharmacology 668 (2011) S70–S80


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肠-肝轴

1998年马歇尔提出了“肠-肝轴”的概念

  • 对肠道和肝脏功能关系的认识提示新的治疗理念,为肠道和肝脏疾病的治疗探寻新的治疗靶点。

Eamonn M. M. Quigley, Gut Bacteria in Health and Disease. Gastro & Hepat Vol 9, 9, 2013, P 560-569.


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肠-肝轴之间的互动

肠道菌群失调,大量G-杆菌繁殖,LPS产生显著增多肠粘膜屏障功能受损

肝功能异常KCs代谢和清除LPS降低,导致肠道功能异常

致病菌和LPS大量移位,经门静脉入肝,损害肝功能。

Gakuhei Son, et al., Contribution of Gut Bacteria to Liver Pathobiology. Gastroe Res and Prac, Vol 2010, Article ID 453563, 13 pages.


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肠肝对话


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肠道菌群致非酒精性脂肪肝

Valentina Tremaroli & Fredrik Bäckhed, Functional interactions between the gut microbiota and host metabolism. NATURE | VOL 489 | 13 SEPTEMBER 2012


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肠道菌群导致脂肪肝

Carmine Finelli and Giovanni Tarantino, NONALCOHOLIC FATTY LIVER DISEASE, DIET AND GUT MICROBIOTA.EXCLI Journal 2014;13:461-490


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肝脏疾病和SIBO


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肠道菌群与代谢性疾病


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肠道菌群增加能量储存

Nathalie M. Delzenne & Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31.


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肠道菌群导致能量聚集

Patrice D Cani and Nathalie M Delzenne, Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Current Opinion in Pharmacology 2009, 9:737–743.


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肠道菌群引发多种代谢疾病


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肠道菌群致肥胖-糖尿病机理

Patrice D. Cani,et al., Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity. Gut Microbes 3:4, 279-288.


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肠道菌群和肥胖


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肠道菌群和肥胖是一个新的热门话题


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肥胖的定义

  • 肥胖病一般被定义作为有 BMI 30 以上。

体重将近900磅(约400公斤)的里基(Ricky Naputi)现年39岁,是世界最重的男子之一。因为体型过于笨重而难以移动,他已经在坐落于太平洋关岛的家中躺了五年之久。


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肥胖和正常人

Amandine Everard & Patrice D. Cani, Diabetes, obesity and gut microbiota. Best Practice & Research Clinical Gastroenterology 27 (2013) 73–83.


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史氏甲烷短杆菌和肥胖

  • 为了确定肠道菌群的改变和验证人体肠道中的乳杆菌或双歧杆菌是否与肥胖或消瘦相关,我们采用定量PCR和乳杆菌选择性培养基分析了68位肥胖志愿者和47位对照的粪便菌群中硬壁菌、拟杆菌、乳酸乳球菌、动物双歧杆菌和若干乳杆菌种的数量。

  • 结果:定量PCR试验中,动物双歧杆菌(OR=0.63; 95% CI 0.39-1.01; P=0.056)和史氏甲烷短杆菌(OR=0.76; 95% CI 0.59-0.97; P=0.03)与正常体重相关,而罗伊氏乳杆菌(OR=1.79; 95% CI 1.03-3.10; P=0.04)与肥胖相关。

Million M, et al., Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii.Int J Obes (Lond). 2011 Aug 9.


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产甲烷肥胖的人有较高的身体质量指数

  • 58人,BMI显着较高的甲烷阳性者(45.2±2.3公斤/米2)比甲烷阴性(38.5±0.8公斤/米2,P= 0.001)。甲烷阳性者也有更大程度的便秘与甲烷相比,阴性者(21.3±6.4比9.5±2.4,P?= .043)。多元回归分析说明了BMI甲烷之间有显着的关系。

  • 结论:这是人类第一次有研究表明,较高浓度的甲烷检测呼气测试是预测显着更大的肥胖超重者。

B.Basseri等,肝脏病杂志胃肠病学杂志,2012年1月8(1):22-28

美国Cedars-Sinai 医学中心


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肠道菌群致肥胖原因

Valentina Tremaroli & Fredrik Bäckhed, Functional interactions between the gut microbiota and host metabolism. NATURE | VOL 489 | 13 SEPTEMBER 2012


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肠道菌群致肥胖原理

Giulio G Muccioli, et al., The endocannabinoid system links gut microbiota to adipogenesis. Molecular Systems Biology 6: 392; p 1-15.


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肠道菌群致肥胖原理

JOHN K. DIBAISE, et al., Gut Microbiota and Its Possible Relationship With Obesity. Mayo Clin Proc. 2008;83(4):460-469.


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不同胖瘦人群肠道菌群数量

Fabrice Armougom, et al., Monitoring Bacterial Community of Human Gut Microbiota Reveals an Increase in Lactobacillus in Obese Patients and Methanogens in Anorexic Patients. PLoS ONE 4(9): e7125.


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肠道菌群和糖尿病


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肠道菌群和I型糖尿病


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肠道菌群和I型糖尿病


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肠道菌群和II型糖尿病

  • Assessment and characterization of gut microbiota has become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 60,000 type-2-diabetes-associated markers and stablished the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial functions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.

Junjie Qin, et al., A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60 (04 October 2012)


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肠道菌群和II型糖尿病

Junjie Qin, et al., A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60 (04 October 2012)


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菌群紊乱导致炎症

June L. Round and Sarkis K. Mazmanian. The gut microbiota shapes intestinal immune responses during health and disease. NATURE REVIEWS | IMMUNOLOGY, VOLUME 9 | MAY 2009 | 313-324.


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肠道菌群紊乱引发的免疫疾病


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肠道菌群紊乱导致过敏和炎症


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肠粘膜屏障损伤导致炎症

Silvio Balzan, et al., Bacterial translocation: Overview of mechanisms and clinical impact. J Gastro & Hepat 22 (2007) 464–471.


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IBD发生机制

Eamonn M. M. Quigley, Gut Bacteria in Health and Disease. Gastro & Hepat Vol 9, 9, 2013, P 560-569.


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致病菌导致IBD

INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;


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SIBO导致肠病

INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;


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肠道菌群对血管疾病的影响

Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.


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肠道菌群致动脉粥样硬化

R. Caesar, et al., Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. J Intern Med 2010; 268: 320–328.


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肠道菌群致癌

INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;


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细菌对免疫和干细胞活动

Won-Jae Lee. Bacterial-modulated host immunity and stem cell activation for gut homeostasis. GENES & DEVELOPMENT 23:2260–2265


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革命带来的机遇

  • 如何应对悄然而来的革命


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调节肠道菌群的方法


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糖尿病治疗新机遇

Re´my Burcelin, Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol (2011) 48:257–273.

Rodrigo Bibiloni, et al., 肠道菌群、肥胖和糖尿病. 雀巢年刊 2009;67:35-43.


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谢谢

联系方式

北美医学教育基金会

电话:010/8208 2279

传真:010/6236 3545

手机:135 0138 5080

手机:001-510/396-6618(美国)

QQ: 834983669

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