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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center PowerPoint PPT Presentation


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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center Department of Biochemistry McGill University Montr é al , Canada. Viruses as tools in the study of cell transformation and apoptosis.

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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center

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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death

Jose G. Teodoro, Ph.D

McGill Cancer Center

Department of Biochemistry

McGill University

Montréal, Canada


Viruses as tools in the study of cell transformation and apoptosis


Viruses as tools in the study of cell transformation and apoptosis


Apoptin localizes in a transformation-dependent manner


Apoptin localization is regulated by a factor in transformed cells


Proteomic analysis of Apoptin-associated proteins


Subunit structure of the APC/C

Thornton et al.

Genes & Dev (2006)


Apoptin induces destabilization of the APC/C

FPLC analysis


Apoptin colocalizes with APC/C within PML bodies


Apoptin colocalizes with APC/C within PML bodies


Tran et al. J Virol. 2007 Oct 17


Overview and future directions

How does G2/M arrest proceed to apoptosis?

Do current chemotherapies rely on APC/C inhibition for efficacy?

Can the APC/C be an anti-cancer drug target?


Acknowledgements

McGill University

Isabelle Gamache

Mohamed Mustafa

Russell Towers

Sarah Assadian

Yiqing Lu

Michael Hell

U Mass

Michael Green

Destin Heilman

Albert Parker

Julie Zhou

Reagents

Frank Graham

Crister Hoog


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