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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center PowerPoint PPT Presentation


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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center Department of Biochemistry McGill University Montr é al , Canada. Viruses as tools in the study of cell transformation and apoptosis.

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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death Jose G. Teodoro, Ph.D McGill Cancer Center

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Viral Inhibition of the Anaphase-Promoting Complex/Cyclosome as a Mechanism of Tumor-specific Cell Death

Jose G. Teodoro, Ph.D

McGill Cancer Center

Department of Biochemistry

McGill University

Montréal, Canada


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Viruses as tools in the study of cell transformation and apoptosis


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Viruses as tools in the study of cell transformation and apoptosis


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Apoptin localizes in a transformation-dependent manner


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Apoptin localization is regulated by a factor in transformed cells


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Proteomic analysis of Apoptin-associated proteins


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Subunit structure of the APC/C

Thornton et al.

Genes & Dev (2006)


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Apoptin induces destabilization of the APC/C

FPLC analysis


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Apoptin colocalizes with APC/C within PML bodies


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Apoptin colocalizes with APC/C within PML bodies


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Tran et al. J Virol. 2007 Oct 17


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Overview and future directions

How does G2/M arrest proceed to apoptosis?

Do current chemotherapies rely on APC/C inhibition for efficacy?

Can the APC/C be an anti-cancer drug target?


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Acknowledgements

McGill University

Isabelle Gamache

Mohamed Mustafa

Russell Towers

Sarah Assadian

Yiqing Lu

Michael Hell

U Mass

Michael Green

Destin Heilman

Albert Parker

Julie Zhou

Reagents

Frank Graham

Crister Hoog


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