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抗原识别受体多样性的产生 和 T 、 B 淋巴细胞的发育 PowerPoint PPT Presentation


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抗原识别受体多样性的产生 和 T 、 B 淋巴细胞的发育. 抗原识别受体多样性的产生. 淋巴细胞抗原识别特点:. 1. TB 细胞都用其抗原识别受体识别抗原 B 细胞: B cell receptor (BCR) T 细胞: T cell receptor (TCR). 2. 一种淋巴细胞仅表达一种抗原受体. 究竟什么样的病原微生物能够突破机体的天然免疫屏障并不能预料。为了能够防御所有可能的病原微生物的感染,特异性免疫应答系统必须能够识别所有可能的外来抗原物质,因此 BCR 和 TCR 必须形成一个巨大的抗原受体库。.

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抗原识别受体多样性的产生 和 T 、 B 淋巴细胞的发育

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TB



1. TB

BB cell receptor (BCR)

TT cell receptor (TCR)

2.


BCRTCR


101235


BCRBCR

BCR

TCR


BCR


BCR

?


BBCR

DreyerBennett1965BCRBCRVBCRCVC


X

X

X

X

X

X

Tonegawa

BCR



DNAVCDNAVCJ (joining)Ddiversity


  • l22k214

  • VCVDJ

  • L(leader)


The Nobel Prize in Physiology or Medicine 1987

For his discovery of the genetic principle for generation of antibody diversity"

Massachusetts Institute of Technology (MIT) Cambridge, MA, USA

Susumu Tonegawa

b.1939


BCR


(1)


k40Vkx 5Jk= 200Vk

l30Vlx 4Jl= 120Vl

65VHx 27DHx 6JH= 11000VH


12/23(12/23 rule)

(recombination signal sequence, RSS):

12/23


2)

k40Vkx 5Jk= 200Vk

l30Vlx 4Jl= 120Vl

65VHx 27DHx 6JH= 11000VH

11000x(200120)=3.5x106V


3

3.5x106


CDRCDR3CDR1CDR2VCDR3VJD

CDR3


VDJ(junction diversity)

DNA


4

BALB/c

(affinity maturation)


5

BB


TCR


BCRTCRTCRBCR


1TCRBCR


TCR30-35%BCRTCR


TCRFab


TCRb, g7 a, d14

TCRagVJbdVDJ


TCR


TCR7912/23


TCR


2TCRBCR


TCRTCRJNTCR


TCRbD


aJ


TCR


TCRBCR

TT

TBTT


TCRBCRBCRTCRBCRTT


TB


B

T


B


B


B4


Nave B

B


BB


B


pre-BIgaIgbl5VpreB


BB

BB510B


B


B


BB


35x106large pre-B1020x106BBpre-BB


BBCRBCRReceptor editing



B


B2


T


TB

TT

abTMHCT


T


T

TT




T

12 x 1085 x 10712 x 1063T98


gdTabT

TTCR



ab


T



34


TAPC


TCR/MHC


avidity hypothesis


  • BT

  • BT


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